Roles of Microglial and Monocyte Chemokines and Their Receptors in Regulating Alzheimer's Disease-Associated Amyloid-β and Tau Pathologies

Frontiers in Neurology
Joana R GuedesJoseph El Khoury

Abstract

Chemokines and their receptors have been shown to affect amyloid-β (Aβ) and tau pathologies in mouse models of Alzheimer's disease (AD) by regulating microglia and monocyte-associated neuroinflammation, microglial movement and monocyte recruitment into the brain. These cells in turn can promote and mediate Aβ phagocytosis and degradation and tau phosphorylation. In this review we discuss published work in this field in mouse models of AD and review what is known about the contributions of microglial and monocyte chemokines and their receptors to amyloid and tau pathologies. We focus on the roles of the chemokine/chemokine receptor pairs CCL2/CCR2, CX3CL1/CX3CR1, CCL5/CCR5, CXCL10/CXCR3 and CXCL1/CXCR2, highlighting important knowledge gaps in this field. A full understanding of the functions of chemokines and their receptors in AD may guide the development of novel immunotherapies for this devastating disease.

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Nov 2, 2018·Psychiatry Investigation·Can Ilgın, Ahmet Topuzoğlu
May 17, 2019·Cellular and Molecular Life Sciences : CMLS·Rashmi Das, Subashchandrabose Chinnathambi
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Jan 25, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Xinru GuNan Si
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Nov 17, 2020·Brain, Behavior, and Immunity·Anne-Laure Hemonnot-GirardHelene Hirbec
Mar 31, 2021·Molecular Neurobiology·Archna SharmaPing Wang
Aug 17, 2021·Journal of Alzheimer's Disease : JAD·Adrián JordaSoraya L Valles

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Methods Mentioned

BETA
RNAseq
flow cytometry
transgenic

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