Roles of Mifepristone on the Regulation of Cytotoxic Lymphocytes and Regulatory T Cells

Gynecologic and Obstetric Investigation
Linxiang LiuLi-Li Huang

Abstract

To investigate the immunologic function of mifepristone, which acts as a contraceptive drug at the level of the decidua. In our hospital, 60 women (less than 63 days of amenorrhea) volunteered to terminate their pregnancies by the uterine suction evacuation method. Immunohistochemically, the transcription factor forkhead box P3 and granzyme B staining were performed to identify regulatory T cells and cytotoxic lymphocytes (CLs) in all operational subjects. CD8 (cytotoxic T cells marker) and CD56 (natural killer cells marker) staining were further performed in order to characterize the CLs subpopulations. A significantly increased number of CLs was found in the decidua treated with mifepristone. Mifepristone increases the expression of CLs in the decidua, and it provides new insights into the immunologic function of mifepristone as a drug used for pregnancy termination.

Citations

Jul 23, 2021·Reproductive Biology and Endocrinology : RB&E·Xiaoyan QinHui Zhang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Adhesion Molecules in the Brain

Cell adhesion molecules found on cell surface help cells bind with other cells or the extracellular matrix to maintain structure and function. Here is the latest research on their role in the brain.

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.

Related Papers

Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
L WangJ Wang
© 2022 Meta ULC. All rights reserved