Roles of miR-278-3p in IBP2 regulation and Bombyx mori cytoplasmic polyhedrosis virus replication

Gene
Ping WuXi-Jie Guo

Abstract

Bombyx mori cytoplasmic polyhedrosis virus (BmCPV) is a major viral pathogen of silkworm and remains a big challenge to the sericultural industry. Insulin-related peptide binding protein 2 (IBP2) gene, induced by BmCPV infection may play an important role in B. mori immune response. MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression at the post-transcriptional level and play an important role in various processes, including immunity and antiviral response. In this study, we identified IBP2 as one of the targets for miR-278-3p by using luciferase reporter assay. Overexpression of miR-278-3p negatively regulates the expression of IBP2 in silkworm larvae and positively regulates the mRNA transcript level of BmCPV. Our results suggest that miR-278-3p may play an important role in BmCPV replication. It's the first report on bmo-miRNAs in response to BmCPV infection and could provide a new clue to explore the molecular mechanism of BmCPV infection and host immunity.

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Citations

Mar 1, 2018·Current Microbiology·Qi TangGuohui Li
Sep 11, 2019·Archives of Insect Biochemistry and Physiology·Luc SweversJingchen Sun
Feb 24, 2021·Archives of Insect Biochemistry and Physiology·Zhendong ZhangXijie Guo
Mar 2, 2021·Frontiers in Immunology·Liang Jiang
May 25, 2021·Frontiers in Physiology·Mian Muhammad AwaisJingchen Sun

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