Roles of Mitochondrial 17β-Hydroxysteroid Dehydrogenase Type 10 in Alzheimer's Disease

Journal of Alzheimer's Disease : JAD
Xue-Ying HeSong-Yu Yang

Abstract

17β-Hydroxysteroid dehydrogenase type 10 is a multifunctional, homotetrameric, mitochondrial protein encoded by the HSD17B10 gene at Xp 11.2. This protein, 17β-HSD10, is overexpressed in brain cells of Alzheimer's disease (AD) patients. It was reported to be involved in AD pathogenesis as the endoplasmic reticulum-associated amyloid-β binding protein (ERAB) and as amyloid-β binding alcohol dehydrogenase (ABAD). However, the exaggerated catalytic efficiencies for ERAB/ABAD in these reports necessitated the re-characterization of the catalytic functions of this brain enzyme. In addition to isoleucine metabolism, 17β-HSD10 is also responsible for the mitochondrial metabolism of neurosteroids such as 5α-androstane-3α,17β-diol and 17β-estradiol. These neurosteroids are inactivated by the oxidation catalyzed by 17β-HSD10. Since neurosteroid homeostasis is presumably essential for cognitive function, analysis of the impact of 17β-HSD10 and its inhibitor, amyloid-β peptide (Aβ), on the metabolism of neuroactive steroids offers a new approach to AD pathogenesis.

References

Apr 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·C T ChungR H Miller
Apr 1, 1996·Journal of Biochemistry·A KobayashiT Hashimoto
Oct 24, 1997·Nature·K Beyreuther, C L Masters
Feb 13, 2001·Molecular and Cellular Endocrinology·X Y HeS Y Yang
Sep 18, 2001·European Journal of Biochemistry·X Y HeS Y Yang
Feb 2, 2002·The Journal of Biological Chemistry·Jeffrey P GreenfieldHuaxi Xu
Apr 16, 2003·American Journal of Human Genetics·Rob OfmanRonald J A Wanders
Apr 30, 2005·Trends in Endocrinology and Metabolism : TEM·Song-Yu YangHorst Schulz
Jan 18, 2006·Molecular and Cellular Endocrinology·Petra LukacikUdo Oppermann
Jan 31, 2007·Annals of the New York Academy of Sciences·Huaxi XuXue Zhang
Jul 10, 2007·Molecular Genetics and Metabolism·Song-Yu YangDavid Miller
Sep 25, 2007·Cell·Hongying YangDavid A Sinclair
Nov 26, 2008·Chemico-biological Interactions·Bengt PerssonUdo Oppermann
May 9, 2009·Biochemical and Biophysical Research Communications·Virginija JazbutyteTheo Pelzer
Aug 27, 2009·Proceedings of the National Academy of Sciences of the United States of America·Song-Yu YangMazhar Malik
Jun 17, 2010·The Journal of Pharmacology and Experimental Therapeutics·Doodipala Samba Reddy, Kuihuan Jian
Jun 29, 2011·Molecular and Cellular Endocrinology·Song-Yu YangDavid Miller
Jul 24, 2012·Trends in Endocrinology and Metabolism : TEM·Liana Roberts Stein, Shin-ichiro Imai
Sep 12, 2012·Journal of Molecular Endocrinology·Silvia GiattiBarbara Viviani
Feb 1, 2014·Current Alzheimer Research·Koteswara R ValaasaniShirley S Yan
May 27, 2014·Journal of Alzheimer's Disease : JAD·Jhansi Rani VangavaraguShirley ShiDu Yan
Jul 11, 2014·The Journal of Steroid Biochemistry and Molecular Biology·Song-Yu YangManfred Philipp
Dec 15, 2015·Neuroscience and Biobehavioral Reviews·Roberto C MelcangiLuis M Garcia-Segura
Sep 22, 2016·Frontiers in Neuroendocrinology·Mariana F UchoaChristian J Pike

❮ Previous
Next ❯

Citations

Jan 31, 2019·Nucleic Acids Research·Valérie de Crécy-LagardJanusz M Bujnicki
Apr 20, 2020·Journal of Neurochemistry·Lucie VinklarovaKamil Musilek
Jul 11, 2020·International Journal of Molecular Sciences·Yvette Akwa
Nov 18, 2018·Journal of Medicinal Chemistry·Ahmed Morsy, Paul C Trippier

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alzheimer's Disease: Amyloid Beta

Alzheimer's disease is a neurodegenerative disease associated with the accumulation of amyloid plaques in the brain; these plaques are comprised of amyloid beta deposits. Here is the latest research in this field.

Alzheimer's Disease: APP

Amyloid precursor protein (APP) proteolysis is critical for the development of Alzheimer's disease, a neurodegenerative disease associated with accumulation of amyloid plaques in the brain. Here is the latest research on APP and Alzheimer's disease.