PMID: 9192244May 1, 1997Paper

Roles of nitric oxide and adenosine in the regulation of coronary conductance in the basal state and during reactive hyperemia

Japanese Circulation Journal
J OtomoH Tomoike

Abstract

Nitric oxide (NO) and adenosine are important mediators in the regulation of coronary vascular tone and are released into the interstitium from the vascular endothelium and myocardium, respectively. The roles of these autacoids in the regulation of coronary flow in the basal and reactive hyperemic states were examined in Langendorff rabbit hearts perfused with oxygenated Krebs-Henseleit solution at 37 degrees C and 110 mmHg pressure. Instantaneous perfusion pressure-flow relationships were analyzed to derive coronary conductance both in the basal state and during the early phase of reperfusion (hyperemic state). N omega-nitro-L-arginine methyl ester (L-NAME) at increasing concentrations (10(-6) to 10(-4) mol/L) (n = 7) and 8-phenyltheophylline (8-PT) at increasing concentrations (10(-9) to 10(-6) mol/L) (n = 7) were applied to assess the role of NO and adenosine, respectively. L-NAME dose-dependently reduced the coronary conductance in both the basal and early hyperemic states, while 8-PT dose-dependently reduced conductance only in the hyperemic state. Changes in conductance during the early hyperemic phase correlated well with changes in the debt repayment ratio for either L-NAME (r = 0.94) or 8-PT (r = 0.99). These data sugg...Continue Reading

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Citations

Mar 25, 2000·Journal of Molecular and Cellular Cardiology·M P KingsburyD J Sheridan
Jan 19, 2005·British Journal of Pharmacology·Amanda J Zatta, John P Headrick
Apr 12, 2003·Redox Report : Communications in Free Radical Research·Yoichi OmoriKazuo Todoki
Dec 13, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Takeshi MatsumotoFumihiko Kajiya
Jul 17, 1999·The American Journal of Physiology·L E DavisM J Morton

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