Roles of noncoding RNAs in metastasis of nonsmall cell lung cancer: A mini review

Journal of Cancer Research and Therapeutics
Tao WuZhijun Zhao

Abstract

Recent advances in genome-wide sequencing and gene expression profiling technologies has facilitated the discovery of a huge amount of long noncoding RNA (lncRNA) transcripts. In general, these lncRNAs have been reported to participate in multiple biological processes and human diseases through transcriptional, posttranscriptional and epigenetic pathway. Furthermore, emerging evidence has suggested that dysregulation of lncRNA contributes to the development and progression of human malignancies, notably lung cancer, which is one of the leading causes of cancer-related death. In this review, we will summarize the functions of lncRNAs from recent reports in human nonsmall cell lung cancer (NSCLC) research, especially in the metastasis of NSCLC, and highlight the future opportunities and challenges in diagnostics and therapy of NSCLC patients.

Citations

Feb 22, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Qingchun LuTao Ren
Apr 19, 2017·Oncotarget·He LiHong-Hao Zhou
Apr 7, 2021·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jinyu ZhangZhi Q Yao

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