Roles of oxidative stress and endoplasmic reticulum stress in selenium deficiency-induced apoptosis in chicken liver

Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
Linlin YaoShiwen Xu

Abstract

Oxidative stress and endoplasmic reticulum (ER) stress are involved in different types of stress-induced injuries. The aim of the present study was to evaluate the effect of Se deficiency on oxidative stress, ER stress and apoptosis in chicken livers. Chickens (1 day old, n = 180) were randomly divided into two groups: the L group [fed with a Se-deficient (Se 0.033 mg/kg) diet] and the control group [fed with a normal (Se 0.2 mg/kg) diet]. Factor-associated oxidative stress, catalase (CAT) activity, H2O2 production and the inhibition of hydroxyl radicals (·OH) in the chicken liver were determined on days 15, 25, 35, 45, 55 and 65, respectively. In addition, ER stress-related genes (GRP78, GRP94, ATF4, ATF6 and IRE) and apoptosis-related genes (caspase3 and Bcl-2) were examined by fluorescence quantitative PCR or western blot analysis. Apoptosis levels were also measured using ultrastructural observations and the TdT-mediated dUTP nick end labeling assay. The results showed that CAT activity and ·OH inhibition were decreased and that H2O2 production was increased in the low-Se group, which demonstrated that oxidative stress occurred in the chicken liver. The ER stress-related genes (GRP78, GRP94, ATF4, ATF6 and IRE) and the apop...Continue Reading

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Citations

Sep 4, 2015·Biological Trace Element Research·Bose KarthikeyanThandavarayan Kathiresan
Oct 7, 2015·Biological Trace Element Research·Jinxin ZhaoShiwen Xu
Oct 17, 2016·Biological Trace Element Research·Pervez Ahmed KhosoShu Li
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Mar 17, 2020·Metallomics : Integrated Biometal Science·Yuan ZhangZiwei Zhang
Sep 25, 2020·Metallomics : Integrated Biometal Science·Yafan GongZiwei Zhang
Apr 1, 2018·Biological Trace Element Research·Changyu CaoKai Wang
Jun 30, 2019·Oxidative Medicine and Cellular Longevity·Yiming ZhangShu Li
Dec 6, 2018·Journal of Cellular Physiology·Yafan GongZiwei Zhang
Jan 10, 2021·Bulletin of Environmental Contamination and Toxicology·Qizhuang LvYulin Zhu

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