Roles of Perilipins in Diseases and Cancers

Current Genomics
Pengpeng ZhangFeng Li

Abstract

Perilipins, an ancient family of lipid droplet-associated proteins, are embedded in a phospho-lipid monolayer of intracellular lipid droplets. The core of lipid droplets is composed of neutral fat, which mainly includes triglyceride and cholesterol ester. Perilipins are closely related to the function of lipid droplets, and they mediate lipid metabolism and storage. Therefore, perilipins play an important role in the development of obesity, diabetes, cancer, hepatic diseases, atherosclerosis, and carcinoma, which are caused by abnormal lipid metabolism. Accumulation of lipid droplets is a common phenomenon in tumor cells. Available data on the pathophysiology of perilipins and the relationship of perilipins with endocrine metabolic diseases and cancers are summarized in this mini-review. The research progress on this family offers novel insights into the therapeutic strategies for these diseases.

Citations

Aug 25, 2020·Biology of Sex Differences·Susan StienenPatrick Rossignol
Mar 22, 2019·Cancers·Anastasia AsimakopoulouRalf Weiskirchen
Dec 21, 2019·Laboratory Investigation; a Journal of Technical Methods and Pathology·Masakazu FujimotoShin-Ichi Murata
Jun 14, 2021·Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids·Arpana Singh, Prosenjit Sen
Jul 28, 2021·Neuropathology and Applied Neurobiology·Maria ConteStefano Salvioli
Sep 28, 2021·BJU International·Jordan G FlitcroftGrant D Stewart

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Methods Mentioned

BETA
antisense nucleotides
xenograft

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