Roles of phosphodiesterases in the regulation of the cardiac cyclic nucleotide cross-talk signaling network

Journal of Molecular and Cellular Cardiology
Claire Y ZhaoRaimond L Winslow

Abstract

The balanced signaling between the two cyclic nucleotides (cNs) cAMP and cGMP plays a critical role in regulating cardiac contractility. Their degradation is controlled by distinctly regulated phosphodiesterase isoenzymes (PDEs), which in turn are also regulated by these cNs. As a result, PDEs facilitate communication between the β-adrenergic and Nitric Oxide (NO)/cGMP/Protein Kinase G (PKG) signaling pathways, which regulate the synthesis of cAMP and cGMP respectively. The phenomena in which the cAMP and cGMP pathways influence the dynamics of each other are collectively referred to as cN cross-talk. However, the cross-talk response and the individual roles of each PDE isoenzyme in shaping this response remain to be fully characterized. We have developed a computational model of the cN cross-talk network that mechanistically integrates the β-adrenergic and NO/cGMP/PKG pathways via regulation of PDEs by both cNs. The individual model components and the integrated network model replicate experimentally observed activation-response relationships and temporal dynamics. The model predicts that, due to compensatory interactions between PDEs, NO stimulation in the presence of sub-maximal β-adrenergic stimulation results in an increas...Continue Reading

References

Sep 1, 1992·British Journal of Pharmacology·T BethkeH Wenzlaff
Feb 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·P F MéryR Fischmeister
Apr 1, 1997·Chemical Research in Toxicology·A Ramamurthi, R S Lewis
Aug 24, 1999·Pharmacology & Therapeutics·J D Graves, E G Krebs
Feb 29, 2000·The Journal of Biological Chemistry·L H JiangD Wray
Nov 28, 2001·The Journal of Biological Chemistry·Sergei D RybalkinJoseph A Beavo
Jan 24, 2002·Nature·Donald M Bers
Jul 18, 2002·Nature Reviews. Drug Discovery·Margaret A Somerville
Aug 15, 2002·Proceedings of the National Academy of Sciences of the United States of America·Beate FiedlerKai C Wollert
Sep 5, 2002·Nature Reviews. Molecular Cell Biology·Joseph A Beavo, Laurence L Brunton
Jun 24, 2003·Journal of Molecular and Cellular Cardiology·Joshua M Hare
Jun 30, 2005·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Paul B MassionJ-L Balligand
Oct 11, 2005·Biophysical Journal·Joseph L GreensteinRaimond L Winslow
Mar 21, 2006·The Journal of Surgical Research·Jacob MoalemPeter M Scholz
May 3, 2006·Circulation·Liliana R V CastroRodolphe Fischmeister
Aug 3, 2006·Nature Reviews. Drug Discovery·Frank S MennitiChristopher J Schmidt
Oct 14, 2006·Circulation Research·Rodolphe FischmeisterGrégoire Vandecasteele
Nov 10, 2006·The New England Journal of Medicine·Ferid Murad
Feb 20, 2007·Circulation Research·Kenji Omori, Jun Kotera
Mar 3, 2007·Circulation Research·Chen YanJun-ichi Abe
May 1, 2007·Cardiovascular Research·David A KassHunter C Champion
Aug 21, 2007·Life Sciences·R RastaldoG Losano
Apr 29, 2008·Free Radical Biology & Medicine·Douglas D ThomasDavid A Wink
Aug 30, 2008·Journal of Molecular and Cellular Cardiology·Mark T ZioloHonglan Wang
Sep 16, 2008·Cellular Signalling·Manling ZhangDavid A Kass

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Citations

Apr 4, 2017·Journal of Molecular and Cellular Cardiology·Claire Y ZhaoRaimond L Winslow
Jan 26, 2018·Journal of Cardiovascular Development and Disease·Nikoleta Pavlaki, Viacheslav O Nikolaev
Feb 7, 2018·Journal of Receptor and Signal Transduction Research·W R Williams
Oct 12, 2018·The Journal of Physiology·E N Bardsley, D J Paterson
Jul 28, 2017·PloS One·Xiaofang WangVicente E Torres
Dec 13, 2017·Oncotarget·Ines BaroneStefania Catalano
Apr 30, 2017·Current Heart Failure Reports·Valentina SalaEmilio Hirsch
Mar 17, 2020·Cardiovascular Drugs and Therapy·Michael E J Preedy

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