PMID: 2116767Aug 15, 1990Paper

Roles of pituitary hormones in the regulation of hepatic cytochrome P450IIE1 in rats and mice

Archives of Biochemistry and Biophysics
J Y HongC S Yang

Abstract

Cytochrome P450IIE1 (P450IIE1) is responsible for the metabolic activation of N-nitrosodimethylamine (NDMA), a potent environmental carcinogen. This P450 enzyme displays a high-affinity NDMA demethylase (NDMAd) activity and is known to be induced by fasting and acetone administration. In the present work, the effects of pituitary hormones on the regulation of P450IIE1 in the liver were investigated and compared in rats and mice. There was no difference in liver microsomal NDMAd activity (nmol/min/mg protein) in rats in the intact (0.38 +/- 0.12), sham-operated (0.44 +/- 0.06), and hypophysectomized (0.52 +/- 0.04) groups. However, hypophysectomy caused a 2-fold increase in hepatic P450IIE1 protein levels as determined by immunoblot analysis. The P450IIE1 mRNA level in hypophysectomized rat was also significantly increased. The levels of blood ketone bodies (acetone, acetoacetate, and beta-hydroxybutyrate) were not different in the intact, sham-operated, and hypophysectomized groups, suggesting that ketone bodies are not involved in the induction of P450IIE1 protein and its mRNA by hypophysectomy. The discrepancy between the NDMAd activity and the increased P450IIE1 protein in rat liver by hypophysectomy can be partially explain...Continue Reading

References

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Citations

Aug 21, 1996·Biochimica Et Biophysica Acta·J SakuraiN Nemoto
Jul 1, 1996·The Journal of Steroid Biochemistry and Molecular Biology·M J CheesmanP E Reilly
Dec 1, 1995·Alcoholism, Clinical and Experimental Research·J L RaucyS P Carpenter
Jul 9, 1999·Alcoholism, Clinical and Experimental Research·C S Lieber
Jan 28, 2004·Annual Review of Pharmacology and Toxicology·Andres A Caro, Arthur I Cederbaum
Dec 15, 2007·Free Radical Biology & Medicine·Yongke Lu, Arthur I Cederbaum
Jul 26, 2006·Expert Opinion on Drug Metabolism & Toxicology·Jose M Jimenez-Lopez, Arthur I Cederbaum
Mar 9, 2002·Toxicology and Applied Pharmacology·Shuxin ZhangWayne L Backes
Jul 16, 2005·Toxicology and Applied Pharmacology·Defeng Wu, Arthur I Cederbaum
Mar 22, 2006·Toxicological Sciences : an Official Journal of the Society of Toxicology·Jingxiang Bai, Arthur I Cederbaum
Jan 1, 1993·Critical Reviews in Toxicology·J L RaucyJ M Lasker
Jun 24, 1999·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·G F ChenT M Badger
Apr 4, 2013·American Journal of Physiology. Endocrinology and Metabolism·Maria KonstandiFrank J Gonzalez
Nov 15, 1992·Archives of Biochemistry and Biophysics·J PanC S Yang

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