PMID: 9169584Jun 1, 1997Paper

Roles of rDNA spacer and transcription unit-sequences in X-Y meiotic chromosome pairing in Drosophila melanogaster males

Chromosoma
X RenB D McKee

Abstract

Meiotic pairing of the X and Y chromosomes in Drosophila melanogaster males is mediated by the rDNA repeats, which are present in two tandem clusters, one in the centric X heterochromatin and the other near the base of the short arm of the Y chromosome. Deletion of the X chromosomal rDNA cluster disrupts X-Y pairing and causes high frequences of X-Y nondisjunction. Pairing can be partly restored by insertions of cloned complete rRNA genes or by rDNA fragments that include the intergenic spacer (IGS) region. A 240 bp repeated sequence in the IGS was shown to be effective in promoting pairing when present at copy numbers above five. This study further defines the rDNA sequences involved in mediating pairing. Germline insertions of a P element construct containing most of the rDNA transcription unit but no promoter or IGS region were obtained. Two single-copy insertions and four two-copy insertions proved unable to stimulate X-Y disjunction when located on an rDNA-deficient X chromosome. In addition, three insertions of a P element construct consisting of the IGS and promoter regions of the rDNA were characterized molecularly. These three insertions had previously been shown to range in pairing ability from very weak to quite stro...Continue Reading

Citations

Mar 2, 2010·Journal of Molecular Evolution·Cheryl D Ambrose, Teresa J Crease
Nov 26, 2009·Genome Génome / Conseil National De Recherches Canada·Mamta SinghW S Lakra
Jun 26, 1999·Genome Génome / Conseil National De Recherches Canada·M MandrioliU Bianchi
May 17, 2014·PLoS Genetics·Josephine A ReinhardtGerald S Wilkinson
Oct 23, 2012·Spermatogenesis·Bruce D McKeeJui-He Tsai
Aug 4, 2016·Frontiers in Cell and Developmental Biology·Alphy JohnJishy Varghese
Jan 10, 2020·Genetics·Christopher A HyltonJohn E Tomkiel Dean
Oct 23, 1997·Genes & Development·G S Roeder

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