Roles of Retinoic Acid in Germ Cell Differentiation

Current Topics in Developmental Biology
Marius TeletinManuel Mark

Abstract

The modalities of gametogenesis differ markedly between sexes. Female are born with a definitive reserve of oocytes whose size is crucial to ensure fertility. Male fertility, in contrast, relies on a tightly regulated balance between germ cell self-renewal and differentiation, which operates throughout life, according to recurring spatial and temporal patterns. Genetic and pharmacological studies conducted in the mouse and discussed in this review have revealed that all-trans retinoic acid and its nuclear receptors are major players of gametogenesis and are instrumental to fertility in both sexes.

Citations

Jan 14, 2018·Genesis : the Journal of Genetics and Development·Aditi DubeyJean-Pierre Saint-Jeannet
Jul 6, 2019·Development·Norbert B Ghyselinck, Gregg Duester
Nov 28, 2019·Biomolecules·Tsutomu EndoDirk G de Rooij
Jun 5, 2020·Science Advances·Anne-Amandine ChassotMarie-Christine Chaboissier
Oct 30, 2020·Frontiers in Cell and Developmental Biology·Olivier BotmanChristine Wyns
Nov 26, 2020·Journal of Cellular and Molecular Medicine·Maria Giovanna DesimioDonatella Farini
Nov 18, 2020·Reproductive Toxicology·Thomas B KnudsenNancy C Baker
Feb 28, 2020·Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids·Maya W HaakerJ Bernd Helms
Sep 17, 2020·Science Advances·Anne-Amandine ChassotMarie-Christine Chaboissier
Sep 3, 2020·Journal of Proteome Research·Rongxia LanShisheng Sun
May 3, 2021·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Michael HaenischJisun Paik

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

European Journal of Haematology
K G van der Hem, G J Ossenkoppele
Perspectives in Biology and Medicine
D W Fawcett
© 2022 Meta ULC. All rights reserved