Roles of RNF126 and BCA2 E3 ubiquitin ligases in DNA damage repair signaling and targeted cancer therapy.

Pharmacological Research : the Official Journal of the Italian Pharmacological Society
Rou ZhangCeshi Chen

Abstract

The dysfunction of E3 ubiquitin ligases is important in the pathogenesis of many human diseases, as they play important roles in multiple cellular processes. In this review, we evaluated the structures, functions and clinical significance of two RING-type E3 ubiquitin ligases from the same subfamily, ring-finger protein 126 (RNF126) and breast cancer associated gene 2 (BCA2). Interestingly, the expression of RNF126 and BCA2 are regulated by multiple signaling pathways, including EGFR, ERK, AKT, and NF-κB. RNF126 and BCA2 appear to be functional mediators for not only DNA damage repair but also cancer development. Due to their significant functions in cell proliferation and DNA damage repair, RNF126 and BCA2 may be two potential diagnostic biomarkers and therapeutic targets for cancers.

Citations

Nov 19, 2020·International Journal of Molecular Sciences·Isabell GöttingJohann Matschke
Mar 9, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Stefano FogliRomano Danesi
Aug 14, 2021·Biochemical and Biophysical Research Communications·Wenjing WuKaishun Hu

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