Roles of Sialic Acid, AXL, and MER Receptor Tyrosine Kinases in Mumps Virus Infection of Mouse Sertoli and Leydig Cells

Frontiers in Microbiology
Fei WangDaishu Han

Abstract

The mumps virus (MuV) causes epidemic parotitis. MuV also frequently infects the testis and induces orchitis, an important etiological factor contributing to male infertility. However, mechanisms underlying MuV infection of the testis remain unknown. Here, we describe that sialic acid, AXL, and MER receptor tyrosine kinases regulate MuV entry and replication in mouse major testicular cells, including Sertoli and Leydig cells. Sialic acid, AXL, and MER were present in Sertoli and Leydig cells. Sialic acid specifically mediated MuV entry into Sertoli and Leydig cells, whereas both AXL and MER facilitated MuV replication within cells through the inhibition of cellular innate antiviral responses. Mechanistically, the inhibition of type 1 interferon signaling by AXL and MER is essential for MuV replication in Sertoli and Leydig cells. Our findings provide novel insights into the mechanisms behind MuV infection and replication in the testis.

References

Jan 1, 1973·Scandinavian Journal of Infectious Diseases·B Bjorvatn
May 31, 2001·Microbiology and Molecular Biology Reviews : MMBR·N Dejucq, B Jégou
May 30, 2003·Reproduction : the Official Journal of the Society for the Study of Fertility·Richard M SharpeJane S Fisher
Jul 13, 2004·Vaccine·Corinne VandermeulenKarel Hoppenbrouwers
Jun 16, 2005·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Huizhen WangDaishu Han
Dec 13, 2005·BJU International·Joe PhilipAnthony D Desmond
Sep 29, 2006·Journal of Virology·Masayuki ShimojimaYoshihiro Kawaoka
Nov 4, 2006·Journal of the Royal Society of Medicine·M MasaraniM Dinneen
Mar 21, 2007·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·J CastillaA Barricarte
Apr 12, 2008·The New England Journal of Medicine·Gustavo H DayanJane F Seward
May 1, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Margaret M CorteseGustavo H Dayan
Jun 26, 2008·Nature Reviews. Immunology·Anthony J Sadler, Bryan R G Williams
Oct 8, 2009·The Medical Journal of Australia·Revle D Bangor-JonesMary M Whitty
Feb 14, 2012·Current Opinion in Virology·John W Schoggins, Charles M Rice
Jun 16, 2012·Frontiers in Immunology·Nan LiDaishu Han
Oct 23, 2012·Cell Host & Microbe·Laurent MeertensAli Amara
Dec 15, 2012·Nature Reviews. Immunology·Michael S Diamond, Michael Farzan
Jul 4, 2013·Molecular Endocrinology·Weiwei ZhuDaishu Han
Mar 13, 2014·Human Vaccines & Immunotherapeutics·Yan LiangQihan Li
Mar 25, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Takehiko ShibataCory M Hogaboam
Jun 24, 2014·Cellular & Molecular Immunology·Shutao ZhaoDaishu Han
Sep 18, 2014·The Journal of Pathology·Steven RubinW Paul Duprex
Jan 17, 2015·Annual Review of Immunology·Carla V RothlinSourav Ghosh
May 8, 2015·PLoS Pathogens·Donald R Latner, Carole J Hickman
Nov 14, 2015·Nature Communications·Yue LiuMichael G Rossmann
Dec 29, 2015·Frontiers in Bioscience (Landmark Edition)·Tingting DengDaishu Han
Sep 28, 2016·Proceedings of the National Academy of Sciences of the United States of America·Marie KubotaTakao Hashiguchi
Dec 9, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Leena N PatelJennifer B Rosen
Jan 5, 2017·Circulation Research·Ingrid Fleming
Feb 9, 2017·Proceedings of the National Academy of Sciences of the United States of America·Audrey Stéphanie RichardHyeryun Choe
Apr 20, 2017·Cell Reports·Andrew K HastingsAkiko Iwasaki
Aug 9, 2017·The Journal of General Virology·Zhao-Yang WangJing An
Sep 20, 2017·Proceedings of the National Academy of Sciences of the United States of America·Wentao LiBerend-Jan Bosch
May 23, 2018·Vaccine·R RamanathanG A Poland
Dec 21, 2018·Andrologia·Weihua LiuDaishu Han
Mar 23, 2019·Emerging Microbes & Infections·Chee Wah TanLin-Fa Wang
Aug 28, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Han WuDaishu Han

❮ Previous
Next ❯

Citations

Mar 9, 2021·Frontiers in Immunology·Ran ChenDaishu Han
Apr 6, 2021·Frontiers in Immunology·Han WuDaishu Han
Apr 30, 2021·Seminars in Cell & Developmental Biology·Rachel L WashburnJannette M Dufour

❮ Previous
Next ❯

Methods Mentioned

BETA
FCS
PCR
protein assay
ELISA
gene knockout
GTPase
GTPase1

Software Mentioned

SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.