Roles of spermine in modulating the antioxidant status and Nrf2 signalling molecules expression in the thymus and spleen of suckling piglets-new insight

Journal of Animal Physiology and Animal Nutrition
Wei CaoGuangmang Liu

Abstract

This study aimed to investigate the effects of spermine and extended spermine administration on the antioxidant status and expression of NF-E2-related factor 2 (Nrf2) signalling molecules in the thymus and spleen in suckling piglets. One half of eighty 12-day-old suckling piglets obtained sufficient nutrient intake supplemented with spermine (0.4 mmol/kg body weight), and another half received restricted nutrient intake supplemented with physiological saline in equal doses once a day for 7 hr or 3, 6 or 9 days in pairs. Spermine supplementation and its extended duration significantly decreased malondialdehyde (MDA) and protein carbonyl (PC) contents (p < .05), but markedly improved antisuperoxide anion (ASA), antihydroxyl radical (AHR), catalase (CAT), total superoxide dismutase (T-SOD), total antioxidant capacity (T-AOC), glutathione peroxidase (GPx) and glutathione-S-transferase (GST) activities (p < .05) and glutathione (GSH) content (p < .05) in the thymus and spleen. Additionally, real-time PCR analysis showed that spermine administration and extended spermine intake reduced Kelch-like ECH-associated protein 1 (Keap1) gene transcription and enhanced SOD1, GPx1, CAT, glutathione reductase (GR) and Nrf2 mRNA levels of the th...Continue Reading

References

Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Apr 9, 2002·Clinical Biochemistry·Bilgin OzmenOya Bayindir
Feb 28, 2004·The Journal of Nutrition·Guoyao WuNancy D Turner
May 19, 2006·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Ming-Yu HungGow-Chin Yen
Sep 14, 2006·Annual Review of Pharmacology and Toxicology·Thomas W KenslerShyam Biswal
Sep 19, 2006·The International Journal of Biochemistry & Cell Biology·Marian ValkoJoshua Telser
Oct 4, 2006·Free Radical Biology & Medicine·Irina G SavaAntonio Toninello
Oct 28, 2006·Toxicologic Pathology·Mark F Cesta
Oct 28, 2006·Toxicologic Pathology·Gail Pearse
Aug 1, 2009·The International Journal of Biochemistry & Cell Biology·Kazuei Igarashi, Keiko Kashiwagi
Oct 15, 2009·Developmental and Comparative Immunology·Francisco J Pérez-CanoMargarida Castell
Jun 22, 2012·BMC Evolutionary Biology·Fabio PolticelliManuela Cervelli
Oct 3, 2012·Progress in Neurobiology·Meijuan ZhangFeng Zhang
Jan 25, 2013·Proceedings of the National Academy of Sciences of the United States of America·Swati MandalMyung Hee Park
Feb 27, 2013·Journal of Genetics and Genomics = Yi Chuan Xue Bao·Nana Fan, Liangxue Lai
May 2, 2013·Journal of Animal Science and Biotechnology·Joy M CampbellJavier Polo
Dec 20, 2013·Journal of Animal Science·J YinY L Yin
Jan 8, 2014·IUBMB Life·Anthony E Pegg
Aug 28, 2014·Journal of Agricultural and Food Chemistry·Guangmang LiuBai Xue
Jun 6, 2015·American Journal of Physiology. Gastrointestinal and Liver Physiology·Xia XiongYulong Yin
Dec 29, 2015·Frontiers in Bioscience (Landmark Edition)·Xia XiongYulong Yin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.