Roles of STAT3 in leukemia (Review)

International Journal of Oncology
Yin ShiXia Li

Abstract

Leukemia is a type of hematopoietic malignancy, and the incidence rate in the United States and European Union increases by an average of 0.6 to 0.7% annually. The incidence rate in China is approximately 5.17/100,000 individuals, and the mortality rate is 3.94/100,000 individuals. Leukemia is the most common tumor affecting children and adults under 35 years of age, and is one of the major diseases leading to the death of adolescents. Signal transducer and activator of transcription 3 (STAT3) is a vital regulatory factor of signal transduction and transcriptional activation, and once activated, the phosphorylated form of STAT3 (p-STAT3) is transferred into the nucleus to regulate the transcription of target genes, and plays important roles in cell proliferation, differentiation, apoptosis and other physiological processes. An increasing number of studies have confirmed that the abnormal activation of STAT3 is involved in the development of tumors. In this review, the roles of STAT3 in the pathogenesis, diagnosis, treatment and prognosis of leukemia are discussed in the aspects of cell proliferation, differentiation and apoptosis, with the aim to further clarify the roles of STAT3 in leukemia, and shed light into possible novel...Continue Reading

References

Jan 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·M KrönkeK Pfizenmaier
Mar 28, 1995·Proceedings of the National Academy of Sciences of the United States of America·H M SeidelJ Rosen
May 23, 1998·Annual Review of Immunology·W J Leonard, J J O'Shea
Aug 26, 1998·Leukemia & Lymphoma·A Chakraborty, D J Tweardy
Nov 21, 1998·Journal of Leukocyte Biology·A Chakraborty, D J Tweardy
Sep 15, 1999·Proceedings of the National Academy of Sciences of the United States of America·A WoetmannN Odum
Dec 3, 1999·Advances in Pharmacology·C Schindler, I Strehlow
Jun 3, 2000·Annual Review of Immunology·J BanchereauK Palucka
Jun 13, 2000·Oncogene·T BowmanR Jove
Jun 13, 2000·Oncogene·P J CofferR P de Groot
Oct 25, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·S T Ahmed, L B Ivashkiv
May 5, 2001·Leukemia Research·R L Ilaria
May 8, 2001·Molecular and Cellular Biology·L M JohansenD G Tenen
Jun 29, 2001·Nature Immunology·Y J LiuM Gilliet
Dec 14, 2002·Blood·Mustafa BenekliMeir Wetzler
Jun 25, 2003·Expert Review of Anticancer Therapy·Alberto RedaelliMarc F Botteman
Feb 18, 2004·Nature Reviews. Cancer·Hua Yu, Richard Jove
May 3, 2005·Nature Reviews. Immunology·Leonidas C Platanias
Aug 5, 2006·Blood·Athanasia D PanopoulosStephanie S Watowich
Dec 23, 2006·Nature Reviews. Immunology·Hua YuDrew Pardoll
Jun 22, 2007·Immunity·Li Wu, Yong-Jun Liu
Sep 21, 2007·Journal of Cellular Biochemistry·Verónica Julieta Marino, Leonor Patricia Roguin
Apr 25, 2008·Biochemical and Biophysical Research Communications·Zhiyong RenXiaomin Chen
May 30, 2008·Frontiers in Bioscience : a Journal and Virtual Library·Sarah DewildeValeria Poli
Jul 16, 2008·Seminars in Cell & Developmental Biology·Bernd GronerCorina Borghouts
Oct 25, 2008·Cytokine & Growth Factor Reviews·Julie PiessevauxJan Tavernier
Dec 5, 2008·Expert Opinion on Investigational Drugs·Peibin Yue, James Turkson
May 26, 2010·Leukemia & Lymphoma·Ling-di MaLei Xia
Dec 31, 2010·Blood·Thierry Lamy, Thomas P Loughran
Nov 23, 2011·Journal of Clinical and Experimental Hematopathology : JCEH·Yoshihiro KomoharaMotohiro Takeya

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

© 2022 Meta ULC. All rights reserved