Roles of the arcuate nucleus and ovary in the maturation of growth hormone, prolactin, and nongranulated cells in the mouse adenohypophysis during postnatal development: a stereological morphometric study by electron microscopy

Endocrinology
F Sasaki, M Sano

Abstract

With the use of monosodium L-glutamate (MSG) treatment and ovariectomy, we studied how the arcuate nucleus and ovary are involved in the maturation of GH, PRL, and nongranulated cells in the anterior pituitary lobe during postnatal development. From day 1 to day 7 female pups were injected sc daily with MSG (2 mg/g BW) (MSG mice) or distilled water (control mice). Just before puberty (at 30 days of age) some control and MSG mice were ovariectomized (OVX) (control + OVX mice and MSG + OVX mice, respectively). All animals were killed at 60-70 days of age by decapitation. Populations of GH, PRL, and nongranulated cells in the anterior pituitary lobe were calculated by applying morphometric procedures. Percentages of GH, PRL, and nongranulated cells in MSG mice were not different from those of control mice. In control + OVX mice the percentage of GH cells was greater than that of control mice, while PRL cells were markedly decreased. On the other hand, in MSG + OVX mice the percentage of PRL cells was less than that of MSG mice, while GH cells showed no difference; nongranulated cells were increased. The number of parenchymal cells in the anterior pituitary lobe in MSG mice was approximately two thirds that of control mice. The par...Continue Reading

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