PMID: 8970975Dec 1, 1996Paper

Roles of the auxiliary genes and AP-1 binding site in the long terminal repeat of feline immunodeficiency virus in the early stage of infection in cats

Journal of Virology
Y InoshimaT Mikami

Abstract

To examine the roles of auxiliary genes and the AP-1 binding site in the long terminal repeat of feline immunodeficiency virus (FIV) in vivo, three mutant viruses, which are defective in the vif gene ([delta]vif), ORF-A gene (deltaORF-A), and AP-1 binding site (deltaAP-1), and wild-type virus as a positive control were separately inoculated into three specific-pathogen-free cats. These cats were assessed by measuring the number of proviral DNA copies in peripheral blood mononuclear cells (PBMCs), the CD4/CD8 ratio and antibody responses to FIV for 16 weeks and then examining histological changes at necropsy. Although viral DNAs were detected in PBMCs from all 12 cats to various degrees until 16 weeks postinoculation, no virus was recovered from PBMCs of cats infected with (delta)vif virus during the observation period. However, a very weak antibody response was induced in one cat infected with the (delta)vif virus. In contrast, despite the successful recovery of virus from both groups of cats infected with deltaORF-A and deltaAP-1 virus, antibody responses and decrease in the CD4/CD8 ratio in the groups were milder than those in cats infected with wild-type virus. Furthermore, the numbers of proviral DNA copies in PBMCs from th...Continue Reading

References

Jan 1, 1992·Archives of Virology·T FuruyaT Mikami
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Aug 1, 1991·Journal of Virology·T KiyomasuT Mikami
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Jul 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·L DesGroseillersP Jolicoeur
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Jan 1, 1994·Archives of Virology·T MiyazawaT Mikami
Aug 1, 1996·The Journal of General Virology·K Tomonaga, T Mikami

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Citations

Jan 11, 2003·Clinical and Diagnostic Laboratory Immunology·Mariko KohmotoTakayuki Miyazawa
Jul 30, 2003·Journal of Virology·Malou C GemenianoEllen E Sparger
May 10, 2013·Journal of Virology·Ryan M TroyerSue VandeWoude
Aug 17, 2004·Journal of Virology·Sohela de RozièresJohn H Elder
Sep 18, 2007·The Journal of General Virology·Xiaoying ShenEllen E Sparger

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