Roles of the bacterial cell wall and capsule in induction of tumor necrosis factor alpha by type III group B streptococci.

Infection and Immunity
J G VallejoM S Edwards

Abstract

Group B streptococci (GBS) are the major cause of sepsis and fatal shock in neonates in the United States. The precise role of tumor necrosis factor alpha (TNF-alpha) in the development of human GBS sepsis has not been defined; however, whole GBS have been shown to induce the production of this inflammatory cytokine. We sought to determine which bacterial cell wall components of GBS are responsible for triggering TNF-alpha production. Human cord blood monocytes were stimulated with encapsulated (COH1) or unencapsulated (COH1-13) whole type III GBS or with purified bacterial components, including type III capsular polysaccharide (III-PS), group B polysaccharide (GB-PS), lipoteichoic acid (LTA), or peptidoglycan (PG). Lipopolysaccharide from Escherichia coli served as a control. Supernatants were harvested at specific timed intervals, and TNF-alpha levels were measured by enzyme-linked immunosorbent assay. Monocytes exposed to COH1 and COH1-13 induced similar amounts of TNF-alpha. III-PS, GB-PS, LTA, and PG each induced TNF-alpha in a time- and concentration-dependent manner. However, TNF-alpha release was significantly greater after stimulation by the GB-PS or PG than after stimulation by III-PS or LTA (P < 0.05). Our findings i...Continue Reading

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Citations

Apr 22, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Philipp HennekePatrick Trieu-Cuot
Dec 12, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·P HennekeD T Golenbock
Jul 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Giuseppe MancusoGiuseppe Teti
Sep 23, 2008·Expert Reviews in Molecular Medicine·Heather C MaiseyVictor Nizet
Jul 24, 2004·Infection and Immunity·Hiroshige MikamoAndrew B Onderdonk
Sep 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Philipp HennekeDouglas T Golenbock
Oct 26, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·D L HornJ B Zabriskie
May 23, 2006·Infection and Immunity·Philipp Henneke, Reinhard Berner
May 19, 2006·FEMS Immunology and Medical Microbiology·Mariela SeguraMarcelo Gottschalk
Jun 22, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·J G VallejoN Sivasubramanian
Jan 4, 2001·Microbes and Infection·B Spellerberg

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