PMID: 7031711Oct 1, 1981Paper

Roles of the relA(+) gene and of 4-thiouridine in near-ultraviolet (344 nm) radiation inhibition of induced synthesis of tryptophanase in Escherichia coli B/r

Photochemistry and Photobiology
R C SharmaJ Jagger

Abstract

Near-ultraviolet radiation (near UV; 300-380 nm) is known to inhibit the induced synthesis of tryptophanase by tryptophan in Escherichia coli, showing an action spectrum similar to that for near-UV-induced growth delay. The present work shows that a relA mutant of E. coli B/r exhibits 50% as much monochromatic near-UV (334 nm) inhibition of tryptophanase induction as the wild type, and tht a mutant lacking 4-thiouridine, an unusual nucleoside in tRNA, exhibits greater than 10% as much inhibition of tryptophanase induction. These findings indicate that 4-thiouridine is almost the sole chromophore for this effect in E. coli B/r, but that only 50% of the effect operates by a mechanism utilizing the relA(+) gene product; growth delay appears not to be primarily involved.

References

May 1, 1976·Cell·A J van OoyenP Jorgensen
Dec 1, 1977·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·O SaporaM Quintiliani
Nov 1, 1976·Journal of Bacteriology·T V RamabhadranJ Jagger
Oct 27, 1975·Biochemical and Biophysical Research Communications·G Thomas, A Favre
Jan 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·T V Ramabhadran, J Jagger
Jan 1, 1971·Journal of Bacteriology·J L Botsford, R D DeMoss
Jan 1, 1972·Journal of Bacteriology·J L Botsford, R D Demoss
May 28, 1971·Journal of Molecular Biology·A FavreM Yaniv
Apr 29, 1961·Biochimica Et Biophysica Acta·A B PARDEE, L S PRESTIDGE
Dec 4, 1962·Biochimica Et Biophysica Acta·R O BURNS, R D DEMOSS

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Dec 1, 1981·Photochemistry and Photobiology·J Jagger

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