Roles of the TGF-β⁻VEGF-C Pathway in Fibrosis-Related Lymphangiogenesis

International Journal of Molecular Sciences
Hiroshi KinashiYoshifumi Takei

Abstract

Lymphatic vessels drain excess tissue fluids to maintain the interstitial environment. Lymphatic capillaries develop during the progression of tissue fibrosis in various clinical and pathological situations, such as chronic kidney disease, peritoneal injury during peritoneal dialysis, tissue inflammation, and tumor progression. The role of fibrosis-related lymphangiogenesis appears to vary based on organ specificity and etiology. Signaling via vascular endothelial growth factor (VEGF)-C, VEGF-D, and VEGF receptor (VEGFR)-3 is a central molecular mechanism for lymphangiogenesis. Transforming growth factor-β (TGF-β) is a key player in tissue fibrosis. TGF-β induces peritoneal fibrosis in association with peritoneal dialysis, and also induces peritoneal neoangiogenesis through interaction with VEGF-A. On the other hand, TGF-β has a direct inhibitory effect on lymphatic endothelial cell growth. We proposed a possible mechanism of the TGF-β⁻VEGF-C pathway in which TGF-β promotes VEGF-C production in tubular epithelial cells, macrophages, and mesothelial cells, leading to lymphangiogenesis in renal and peritoneal fibrosis. Connective tissue growth factor (CTGF) is also involved in fibrosis-associated renal lymphangiogenesis through i...Continue Reading

References

Apr 29, 1998·Kidney International·Y ItoR Goldschmeding
Jun 26, 1999·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·K HondaS Horiuchi
Aug 12, 1999·The Journal of Laboratory and Clinical Medicine·M M ZweersR T Krediet
Mar 31, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·K N LaiJ C Leung
May 4, 2000·The American Journal of Pathology·K PaavonenK Alitalo
Oct 12, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·T A PartanenK Alitalo
Sep 29, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·H YokoiK Nakao
Dec 18, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Isao InokiYasunori Okada
Jun 28, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Anne SaaristoKari Alitalo
Jul 23, 2002·Nature Cell Biology·José G AbreuE M De Robertis
Jan 31, 2003·The New England Journal of Medicine·María Yáñez-MóManuel López-Cabrera
Jun 6, 2003·Kidney International·Krystyna H ZarrinkalamRandall J Faull
Jan 16, 2004·Lancet·Bernard Perbal
Feb 6, 2004·Virchows Archiv : an International Journal of Pathology·Katsuyoshi KanemotoMichio Nagata
Feb 24, 2004·Journal of the American Society of Nephrology : JASN·Dontscho KerjaschkiIngrid Raab
May 22, 2004·Journal of the American Society of Nephrology : JASN·Hideki YokoiKazuwa Nakao
Jun 24, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Eric BoulangerJean-Luc Wautier
Dec 3, 2004·Journal of the American Society of Nephrology : JASN·Hirokazu OkadaHiromichi Suzuki
Mar 4, 2005·Molecular and Cellular Biology·Megan E BaldwinMarc G Achen
Mar 17, 2005·Journal of Cellular Biochemistry·Hwai-Shi WangChin-Chang Chen
Oct 29, 2005·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Luiz S AroeiraManuel López-Cabrera
May 4, 2006·British Journal of Cancer·G G Van den EyndenE A Van Marck
Feb 15, 2007·Kidney International·S HuberM Guba
Jun 8, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Mausumee GuhaRama Natarajan
Aug 31, 2007·Histopathology·Y IshikawaT Ishii
Nov 21, 2007·Translational Research : the Journal of Laboratory and Clinical Medicine·Maria CiszewiczAndrzej Breborowicz
Sep 23, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Joseph C K LeungKar Neng Lai

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Citations

Aug 15, 2019·American Journal of Physiology. Renal Physiology·Hui ZhuoYouhua Liu
Jun 13, 2019·International Journal of Impotence Research·Onder CinarNecmettin A Mungan
Mar 7, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Natalie R NielsenKathleen M Caron
Aug 23, 2019·Scientific Reports·Hiroshi KinashiYasuhiko Ito
Aug 28, 2020·World Journal of Stem Cells·Zhu-Jun LiXiao Long
Jan 21, 2021·Experimental Biology and Medicine·Heidi A Creed, Joseph M Rutkowski
Feb 13, 2021·Cancers·Florent MorfoisseBarbara Garmy-Susini
Feb 13, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Bin HuangJiumao Lin
Jan 9, 2021·Signal Transduction and Targeted Therapy·Sijia LiuPeter Ten Dijke
May 25, 2021·Current Opinion in Nephrology and Hypertension·Michael D Donnan
Jun 5, 2021·Inflammation and Regeneration·Hideki AmanoYoshiya Ito
Jun 24, 2021·Nature Reviews. Nephrology·Michael D DonnanSusan E Quaggin

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Methods Mentioned

BETA
biopsies
biopsy
bronchoalveolar lavage
transfection

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