Roles of titin in the structure and elasticity of the sarcomere.

Journal of Biomedicine & Biotechnology
L Tskhovrebova, J Trinick

Abstract

The giant protein titin is thought to play major roles in the assembly and function of muscle sarcomeres. Structural details, such as widths of Z- and M-lines and periodicities in the thick filaments, correlate with the substructure in the respective regions of the titin molecule. Sarcomere rest length, its operating range of lengths, and passive elastic properties are also directly controlled by the properties of titin. Here we review some recent titin data and discuss its implications for sarcomere architecture and elasticity.

References

Aug 1, 1989·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·W Oda-KurioC Inagaki
Jul 1, 1968·The Journal of Cell Biology·G G Knappeis, F Carlsen
Dec 5, 1984·Journal of Molecular Biology·J TrinickA Whiting
Jun 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·K WangD Palter
Jun 1, 1983·The Journal of Cell Biology·R W Kensler, M Stewart
Jun 1, 1983·Journal of Muscle Research and Cell Motility·L TraegerM A Goldstein
Jul 24, 1980·Nature·M C Maw, A J Rowe
Nov 22, 1993·Proceedings. Biological Sciences·A SoteriouJ Trinick
Jan 17, 1997·Journal of Molecular Biology·L Tskhovrebova, J Trinick
Nov 25, 1998·Journal of Molecular Biology·S ImprotaA Pastore
Jan 12, 2001·Journal of Molecular Biology·A D LiversageJ Trinick
Jul 17, 2001·Journal of Molecular Biology·L Tskhovrebova, J Trinick
Aug 2, 2001·Journal of Molecular Biology·P AmodeoA Pastore
Aug 25, 2001·Journal of Muscle Research and Cell Motility·R TatsumiK Takahashi
Jan 29, 2002·Journal of Molecular Biology·Jiang Cheng WangRobin W Briehl
Aug 29, 2002·Nature·Hongbin LiJulio M Fernandez
Sep 25, 2002·Journal of Molecular Biology·Carlo KnuppJohn M Squire
May 27, 2003·Biochimica Et Biophysica Acta·Miklós S Z KellermayerHenk L Granzier
Sep 25, 2003·Nature Reviews. Molecular Cell Biology·Larissa Tskhovrebova, John Trinick
Nov 1, 2003·Proceedings of the National Academy of Sciences of the United States of America·Dietmar LabeitHenk Granzier

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Citations

Feb 25, 2011·Pflügers Archiv : European journal of physiology·Tobias Voelkel, Wolfgang A Linke
Dec 20, 2012·Proceedings of the National Academy of Sciences of the United States of America·Hind A Al-KhayatEdward P Morris
Apr 24, 2012·The Journal of Biological Chemistry·Sergi Garcia-ManyesJulio M Fernández
Jan 25, 2011·The Journal of Biological Chemistry·Martina Krüger, Wolfgang A Linke
Feb 6, 2013·Biochemistry. Biokhimii︠a︡·I M Vikhlyantsev, Z A Podlubnaya
Dec 7, 2014·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Shu-Fen ChenZhan-Ling Dong
May 24, 2015·FEBS Letters·Tracy A CaldwellNathan T Wright
Aug 16, 2014·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·J Layne Myhre, David Pilgrim
Feb 24, 2012·International Journal of Cardiology·Alison L MüllerNaranjan S Dhalla
Mar 6, 2015·Protein Science : a Publication of the Protein Society·Michael W RudloffNathan T Wright
Apr 22, 2014·Journal of Structural Biology·Balázs Kiss, Miklós S Z Kellermayer
Aug 26, 2014·Food Chemistry·Marta GallegoFidel Toldrá
Dec 1, 2014·Cell·Euripedes de Almeida RibeiroKristina Djinović-Carugo
Dec 15, 2017·Nature Reviews. Cardiology·James S Ware, Stuart A Cook
Dec 23, 2017·International Journal of Molecular Sciences·Casey CarlisleDave Pilgrim
May 17, 2018·American Journal of Physiology. Cell Physiology·V JoumaaW Herzog
Mar 15, 2014·Circulation Research·Wolfgang A Linke, Nazha Hamdani
Feb 3, 2011·Journal of Muscle Research and Cell Motility·Thomas M Butler, Marion J Siegman
Apr 15, 2020·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Robert D GerwinKayleigh De Meulemeester
Apr 6, 2019·The Journal of General Physiology·Srboljub M MijailovichHenk L Granzier
Apr 17, 2019·The FEBS Journal·Franziska KoserWolfgang A Linke
Apr 30, 2016·Bioscience Reports·Alexandr G BobylevIvan M Vikhlyantsev
Apr 19, 2019·Journal of Clinical Medicine·Chia-Jung LiMeng-Yu Wu
Jul 10, 2019·Annual Review of Genetics·Donghoon M Lee, Elizabeth H Chen
Jan 15, 2021·Comprehensive Reviews in Food Science and Food Safety·Xin LiLi Chen
May 13, 2015·The Journal of Experimental Biology·Justus O OrtegaKevin E Conley

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Methods Mentioned

BETA
electron microscopy
X-ray
atomic force microscopy
AFM
optical tweezer
NMR

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