Roles of Toll-Like Receptor 2 (TLR2), TLR4, and MyD88 during Pulmonary Coxiella burnetii Infection

Infection and Immunity
Andrew G RamsteadMark A Jutila

Abstract

Coxiella burnetii, the causative agent of Q fever, is an obligate intracellular, primarily pulmonary, bacterial pathogen. Although much is known about adaptive immune responses against this bacterium, our understanding of innate immune responses against C. burnetii is not well defined, particularly within the target tissue for infection, the lung. Previous studies examined the roles of the innate immune system receptors Toll-like receptor 2 (TLR2) and TLR4 in peripheral infection models and described minimal phenotypes in specific gene deletion animals compared to those of their wild-type controls (S. Meghari et al., Ann N Y Acad Sci 1063:161-166, 2005,http://dx.doi.org/10.1196/annals.1355.025; A. Honstettre et al., J Immunol 172:3695-3703, 2004,http://dx.doi.org/10.4049/jimmunol.172.6.3695) . Here, we assessed the roles for TLR2, TLR4, and MyD88 in pulmonary C. burnetii infection and compared responses to those that occurred in TLR2- and TLR4-deficient animals following peripheral infection. As observed previously, neither TLR2 nor TLR4 was needed for limiting bacterial growth after peripheral infection. In contrast, TLR2 and, to a lesser extent, TLR4 limited growth (or dissemination) of the bacterium in the lung and spleen af...Continue Reading

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Citations

Nov 26, 2016·Innate Immunity·James M BattistiMichael F Minnick
Jan 19, 2019·Pathogens and Disease·Fei-Ju LiGaetan Burgio
Aug 6, 2019·Frontiers in Cellular and Infection Microbiology·Lu JiaYi Liu
Feb 26, 2019·Frontiers in Immunology·Lisa KohlRoland Lang
Dec 29, 2020·Veterinary Pathology·Martha A DelaneyCharles W Frevert
Mar 30, 2016·Veterinary Immunology and Immunopathology·Jodi F HedgesMark A Jutila

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