Roles of Toll-like Receptor 7 and 8 in Prevention of Intrauterine Transmission of Hepatitis B Virus

Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology
Ting TianMinyue Dong

Abstract

Approximately 5% of newborns were infected by hepatitis B virus (HBV) via intrauterine transmission, but most of the infants born to HBV-positive mothers are protected from infection. However, the mechanisms by which intrauterine transmission is avoided remain elusive, and the roles of toll-like receptors (TLRs) have been proposed. The aims of this study were to clarify if TLR 7 and 8 are involved in the prevention of intrauterine transmission of HBV. Real time polymerase-chain reaction (PCR) was used to determine the expression of TLRs and cytokines in placenta and trophoblasts. The expression of MyD88 was interfered with small interfering RNA (siRNA) in trophoblasts. An in intro model mimicking trophoblast barrier was established to evaluate the effect of MyD88 siRNA on HBV transmission across trophoblast barrier. There were significant differences in placental expression of TLR7 (F=3.263, P=0.048) and TLR8 (F=3.257, P=0.048) among control (HBV-negative women), non-infected group (HBV-positive women whose infants were not infected) and infected group (HBV-positive women whose infants were infected). The expression of TLR7 was significantly higher in non-infected group than infected group (P=0.039) and control (P=0.043). There...Continue Reading

Citations

Jul 5, 2016·Life Sciences·Zahra SepehriDerek Kennedy
Dec 13, 2016·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Xiaoxia BaiMinyue Dong
Aug 29, 2020·Archives of Gynecology and Obstetrics·Peng ZhaoXiaoxia Bai
Sep 19, 2020·Microorganisms·Magda Rybicka, Krzysztof Piotr Bielawski
Jun 23, 2016·World Journal of Hepatology·Zhi-Qiang ZouJi-Guang Yu
Apr 4, 2021·International Journal of Molecular Sciences·Kavita NarangRegan N Theiler
Jun 17, 2021·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·Yihong ChenShan Zheng
Nov 16, 2021·Journal of Medical Microbiology·Sirinart SirilertNipon Chattipakorn

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.