Roles of UVA radiation and DNA damage responses in melanoma pathogenesis

Environmental and Molecular Mutagenesis
Aiman Q KhanMichael G Kemp

Abstract

The growing incidence of melanoma is a serious public health issue that merits a thorough understanding of potential causative risk factors, which includes exposure to ultraviolet radiation (UVR). Though UVR has been classified as a complete carcinogen and has long been recognized for its ability to damage genomic DNA through both direct and indirect means, the precise mechanisms by which the UVA and UVB components of UVR contribute to the pathogenesis of melanoma have not been clearly defined. In this review, we therefore highlight recent studies that have addressed roles for UVA radiation in the generation of DNA damage and in modulating the subsequent cellular responses to DNA damage in melanocytes, which are the cell type that gives rise to melanoma. Recent research suggests that UVA not only contributes to the direct formation of DNA lesions but also impairs the removal of UV photoproducts from genomic DNA through oxidation and damage to DNA repair proteins. Moreover, the melanocyte microenvironment within the epidermis of the skin is also expected to impact melanomagenesis, and we therefore discuss several paracrine signaling pathways that have been shown to impact the DNA damage response in UV-irradiated melanocytes. Las...Continue Reading

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Citations

Aug 17, 2018·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Anne E CustMarianne Berwick
Apr 11, 2019·Melanoma Research·Philippe Autier, Jean-François Doré
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Dec 20, 2020·Cancer Genetics·Larissa Costa de AlmeidaLeticia Veras Costa-Lotufo
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Jun 3, 2021·Biomolecules·Tae-Hong Kang
Jul 3, 2021·International Journal of Molecular Sciences·Strahil Strashilov, Angel Yordanov
Nov 13, 2021·Photochemistry and Photobiology·Chaochao LiuLéon Sanche
Oct 6, 2020·International Journal of Women's Dermatology·Lindsey GoddardJane Hirokane

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