Rolipram and SP600125 suppress the early increase in PTP1B expression during cerulein-induced pancreatitis in rats

Pancreas
Nancy SarmientoJ Sánchez-Yagüe

Abstract

To analyze the expression modulation of pancreatic protein tyrosine phosphatase (PTP)1B during the development of cerulein (Cer)-induced acute pancreatitis (AP) and the effect of inhibition of type 4 phosphodiesterase and c-Jun N-terminal kinase and extracellular signal-regulated kinase 1/2 on its expression levels. Acute pancreatitis was induced in rats by subcutaneous injections of 20 microg Cer per kilogram body weight at hourly intervals, and the animals were killed at 2, 4, or 9 hours after the first injection. Neutropenia was induced with vinblastine sulfate. Phosphodiesterase and the mitogen-activated protein kinases were inhibited with rolipram and SP600125, respectively, before the induction of AP. Protein tyrosine phosphatase 1B increases its expression at the levels of both protein and messenger RNA during the early phase of Cer-induced AP. The increase in protein expression persisted along the development of the disease, and neutrophil infiltration seemed to play a central role. Rolipram and SP600125 pretreatments mostly suppressed the increase in the expression of PTP1B during the early phase of AP. Cerulein-induced AP is associated with an increase in the expression of PTP1B in its early phase. An increase in cycl...Continue Reading

References

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Feb 26, 2008·Biochimica Et Biophysica Acta·Nancy SarmientoJesús Sánchez-Yagüe

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Citations

Apr 22, 2011·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Kyung Don JuHyeyoung Kim
Mar 13, 2014·Cell Communication and Signaling : CCS·Ahmed BettaiebFawaz G Haj
Jan 23, 2016·The International Journal of Biochemistry & Cell Biology·Violeta García-HernándezJesús Sánchez-Yagüe
Oct 12, 2010·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Nancy SarmientoCarmen Sánchez-Bernal

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