PMID: 2510905Nov 6, 1989Paper

Rolipram induces c-fos protein-like immunoreactivity in ependymal and glial-like cells in adult rat brain

Brain Research
M Dragunow, R L Faull

Abstract

We tested the effects of the cyclic AMP-dependent phosphodiesterase inhibitor 4- (3-cyclopentyloxy-4-methoxyphenyl)-2-pyrrolidone (rolipram) on c-fos protein-like immunoreactivity (FOS-IR) in adult rat brain. Rolipram (25-100 mg/kg, i.p.) did not detectability alter basal FOS-IR in neurons but induced FOS-IR in glial-like cells scattered in white matter regions and in ependymal cells lining the lateral and third ventricles. This induction was observed at 1 and 4 h after injection but was not detectable 10 min or 24 h after rolipram injection.

References

Nov 1, 1986·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·A I LeveyB H Wainer
Nov 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·W RanJ Campisi
Nov 23, 1987·Neuroscience Letters·M Dragunow, H A Robertson
Feb 1, 1989·Trends in Biochemical Sciences·J E DumontP P Roger
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Citations

Jan 1, 1991·Molecular Neurobiology·W C AbrahamW P Tate
Apr 1, 1993·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·M Dragunow, P Hughes
Oct 9, 2002·Neuropathology and Applied Neurobiology·X YeR I Carp
Sep 6, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Domenico TuponeShaun F Morrison
May 1, 1995·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R RaghupathiT K McIntosh

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