Rolling blackout, a newly identified PIP2-DAG pathway lipase required for Drosophila phototransduction

Nature Neuroscience
Fu-De HuangKendal Broadie

Abstract

The rolling blackout (rbo) gene encodes an integral plasma membrane lipase required for Drosophila phototransduction. Photoreceptors are enriched for the RBO protein, and temperature-sensitive rbo mutants show reversible elimination of phototransduction within minutes, demonstrating an acute requirement for the protein. The block is activity dependent, indicating that the action of RBO is use dependent. Conditional rbo mutants show activity-dependent depletion of diacylglycerol and concomitant accumulation of phosphatidylinositol phosphate and phosphatidylinositol 4,5-bisphosphate within minutes of induction, suggesting rapid downregulation of phospholipase C (PLC) activity. The RBO requirement identifies an essential regulatory step in G-protein-coupled, PLC-dependent inositol lipid signaling mediating activation of TRP and TRPL channels during phototransduction.

References

Dec 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·K FukamiT Takenawa
Apr 26, 1969·Nature·W L PakN V White
Feb 29, 1984·Biochemical and Biophysical Research Communications·T YoshiokaY Hotta
Jun 7, 1994·Proceedings of the National Academy of Sciences of the United States of America·R W OrdwayB Ganetzky
Mar 1, 1996·The Journal of Biological Chemistry·M T PearnW L Pak
Jan 1, 1997·Methods in Enzymology·M Cygler, J D Schrag
Dec 28, 1999·Annual Review of Cell and Developmental Biology·C Montell
Apr 15, 2000·The Journal of Biological Chemistry·M LiuB H Shieh
Apr 5, 2001·Proceedings of the National Academy of Sciences of the United States of America·E B Rodriguez de TurcoN G Bazan
Sep 15, 2001·Nature·R C Hardie, P Raghu
Dec 6, 2001·Science's STKE : Signal Transduction Knowledge Environment·D W HilgemannC Nasuhoglu
Mar 23, 2002·Journal of Genetics·M KumarS Chandrashekaran
Mar 28, 2002·Physiological Reviews·Baruch Minke, Boaz Cook
Feb 1, 2003·Annual Review of Physiology·Roger C Hardie
Aug 1, 1959·Canadian Journal of Biochemistry and Physiology·E G BLIGH, W J DYER

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Citations

May 27, 2014·Molecular Autism·Abha R GuptaMatthew W State
Feb 8, 2006·Annual Review of Physiology·Baruch Minke, Moshe Parnas
Jun 27, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Scott E PhillipsKendal Broadie
Dec 11, 2008·Journal of Cell Science·Niranjana VijayakrishnanKendal Broadie
Oct 16, 2009·Journal of Lipid Research·Norma M GiustoMónica G Ilincheta de Boschero
Nov 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Ujjaini DasguptaUsha Acharya
Dec 12, 2012·The Journal of Cell Biology·Fubito NakatsuPietro De Camilli
Dec 17, 2008·The Journal of Cell Biology·Dan BairdScott D Emr
Sep 23, 2006·The Journal of Physiology·Roger C Hardie
Apr 11, 2012·Biochimica Et Biophysica Acta·Padinjat RaghuNaresh Babu Naidu Mallampati
Mar 6, 2012·Biochimica Et Biophysica Acta·Marta Koch, Matthew Holt
Feb 9, 2012·Science China. Life Sciences·Yao TianJunhai Han
Jun 23, 2009·Insect Biochemistry and Molecular Biology·Irene HorneJohn G Oakeshott
Jan 11, 2007·Seminars in Cell & Developmental Biology·Padinjat Raghu
Sep 22, 2009·Journal of Neurochemistry·Emma L Clayton, Michael A Cousin
Feb 2, 2015·Current Opinion in Neurobiology·Roger C Hardie, Mikko Juusola
Apr 15, 2011·Journal of Lipids·Susana J PasquaréNorma M Giusto
Apr 14, 2009·Cell Calcium·Padinjat Raghu, Roger C Hardie
Jun 12, 2012·Biochemical and Biophysical Research Communications·Bin ChenAike Guo
Feb 3, 2005·Nature Reviews. Neuroscience·Jeffrey Rohrbough, Kendal Broadie
Mar 24, 2018·Journal of Cell Science·Che-Hsiung LiuRoger C Hardie
Jul 8, 2018·Journal of Cell Science·Sruthi S BalakrishnanPadinjat Raghu
May 10, 2007·Pflügers Archiv : European journal of physiology·Tao Wang, Craig Montell
May 22, 2007·Developmental Neurobiology·Gerald R V Hammond, Giampietro Schiavo
Sep 21, 2007·Nature Reviews. Neuroscience·Daniele PiomelliRao Rapaka
Feb 15, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Qi QianBinggui Sun
Dec 8, 2007·The Biochemical Journal·Isabel MéridaErnesto Merino
Apr 21, 2017·Frontiers in Molecular Neuroscience·Haixia HuMingliang Xiang
Jan 19, 2006·Biochemical Society Transactions·N Vijayakrishnan, K Broadie
Feb 23, 2018·Frontiers in Cellular Neuroscience·Ira Milosevic
Sep 19, 2009·Development·Abhilasha KumarHeinrich Reichert
Aug 2, 2011·Chemical Reviews·Yulia V ShulgaRichard M Epand

❮ Previous
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