PMID: 9532747Apr 9, 1998Paper

Rolling-circle plasmids from Bacillus subtilis: complete nucleotide sequences and analyses of genes of pTA1015, pTA1040, pTA1050 and pTA1060, and comparisons with related plasmids from gram-positive bacteria

FEMS Microbiology Reviews
Wilfried J J MeijerS Bron


Most small plasmids of Gram-positive bacteria use the rolling-circle mechanism of replication and several of these have been studied in considerable detail at the DNA level and for the function of their genes. Although most of the common laboratory Bacillus subtilis 168 strains do not contain plasmids, several industrial strains and natural soil isolates do contain rolling-circle replicating (RCR) plasmids. So far, knowledge about these plasmids was mainly limited to: (i) a classification into seven groups, based on size and restriction patterns; and (ii) DNA sequences of the replication region of a limited number of them. To increase the knowledge, also with respect to other functions specified by these plasmids, we have determined the complete DNA sequence of four plasmids, representing different groups, and performed computer-assisted and experimental analyses on the possible function of their genes. The plasmids analyzed are pTA1015 (5.8 kbp), pTA1040 (7.8 kbp), pTA1050 (8.4 kbp), and pTA1060 (8.7 kbp). These plasmids have a structural organization similar to most other known RCR plasmids. They contain highly related replication functions, both for leading and lagging strand synthesis. pTA1015 and pTA1060 contain a mobiliza...Continue Reading


Jan 1, 1976·Annual Review of Biochemistry·A Meister, S S Tate
Mar 1, 1977·Journal of Bacteriology·T TanakaK Sakaguchi
Apr 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·S D Ehrlich
Aug 1, 1977·Journal of Bacteriology·T Tanaka, T Koshikawa
Feb 1, 1992·Bioscience, Biotechnology, and Biochemistry·T HaraS Ueda
Nov 1, 1992·Trends in Biochemical Sciences·R E Dalbey, G von Heijne
Mar 1, 1992·The Biochemical Journal·M T BlackA E Allsop
Jul 1, 1992·Journal of Bacteriology·J P Mueller, A L Sonenshein
Sep 1, 1991·Research in Microbiology·S BronP Haima
May 1, 1991·Molecular & General Genetics : MGG·F F XuP L Yu
Feb 1, 1989·Journal of Bacteriology·K M DevineD J McConnell
Sep 1, 1989·Journal of Bacteriology·H SuzukiT Tochikura
Jan 1, 1989·Annual Review of Microbiology·R P Novick
Sep 1, 1989·Journal of Bacteriology·S D Priebe, S A Lacks
Sep 1, 1987·Molecular & General Genetics : MGG·P HaimaG Venema
May 1, 1988·Plasmid·S J Projan, R P Novick
Nov 1, 1987·Journal of Bacteriology·T M Koehler, C B Thorne
Apr 1, 1988·Biochimie·J Kok, G Venema
Dec 23, 1988·Nucleic Acids Research·Jacques Mahillon, J Seurinck
Nov 1, 1987·Molecular & General Genetics : MGG·M MuraiY Oshima
Jun 1, 1987·Journal of Bacteriology·M L GennaroR P Novick
Jun 11, 1986·Nucleic Acids Research·G von Heijne
Sep 1, 1965·Proceedings of the National Academy of Sciences of the United States of America·P SchaefferJ P Aubert


Mar 17, 2001·Molecular Microbiology·Muthusamy KunnimalaiyaanPatricia S Vary
Feb 25, 2011·PLoS Biology·Vijay ParasharMatthew B Neiditch
Jan 5, 2012·PLoS Biology·Melinda D Baker, Matthew B Neiditch
Mar 26, 2013·PLoS Biology·Francisca Gallego del Sol, Alberto Marina
Sep 7, 2000·Microbiology and Molecular Biology Reviews : MMBR·H TjalsmaJ M van Dijl
Jun 4, 2005·Applied and Environmental Microbiology·Muthusamy Kunnimalaiyaan, Patricia S Vary
Dec 31, 2005·Journal of Bacteriology·Cristina BongiorniMarta Perego
Feb 17, 2017·PLoS Genetics·Gayetri RamachandranWilfried J J Meijer
May 27, 2005·Molecular Microbiology·Jan-Willem VeeningOscar P Kuipers
Feb 21, 2004·FEMS Microbiology Reviews·M Victoria FranciaFernando de la Cruz
Jul 12, 2012·Environmental Microbiology·Praveen K SinghWilfried J J Meijer
Jul 6, 2014·FEMS Microbiology Letters·Praveen K Singh, Wilfried J J Meijer
Dec 12, 2012·International Journal of Molecular Sciences·Yanhua CuiHongyu Cui
Aug 19, 2018·Microbial Cell Factories·Megumi MiyanoKen-Ichi Yoshida
Nov 7, 2003·Applied and Environmental Microbiology·Michael D SchollePatricia S Vary
Sep 18, 2015·The Journal of General and Applied Microbiology·Huanhuan ShaoHong Feng
Feb 20, 2020·Journal of Bacteriology·Abel Verdugo-FuentesMayra de la Torre
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