Rolling in the clover: trefoil factor family (TFF)-domain peptides, cell migration and cancer

FEBS Letters
N A WrightL Thim

Abstract

Trefoil factor family (TFF)-domain peptides 1-3 are mucin-associated molecules, largely found in epithelia of gastrointestinal tissues. Structurally similar, resistant to enzymatic degradation, they are up-regulated around areas of epithelial damage such as ulcers. Transgenic expression or exogenous peptide ameliorates or prevents gastric mucosal damage due to indomethacin and some are rapidly up-regulated after cryogenic burns. A role in promoting cell migration is strongly suggested. Knockout mice lacking TFF1 or TFF3 show significant pathology, with the former developing gastric tumours. A recent Conference Philippe Laudat agreed upon a new nomenclature for these peptides.

References

Jul 1, 1993·Trends in Biochemical Sciences·W Hoffmann, F Hauser
Feb 1, 1994·Proceedings of the National Academy of Sciences of the United States of America·A DeP S Freemont
Jan 15, 1996·European Journal of Biochemistry·W R OttoN A Wright
Jan 1, 1996·Cytogenetics and Cell Genetics·H SchmittN Blin
Mar 5, 1996·Proceedings of the National Academy of Sciences of the United States of America·R J PlayfordA M Hanby

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Citations

Jul 17, 1998·The Journal of Pathology·D G WangK D Buchanan
Jul 16, 2008·Inflammatory Bowel Diseases·Michael A McGuckinGraham Radford-Smith
May 21, 2005·Peptides·Haibo WangBinggen Ru
Feb 11, 1999·Pharmacology, Biochemistry, and Behavior·H SchwarzbergW Hoffmann
Jul 31, 2002·Biochimica Et Biophysica Acta·Ida B ThøgersenJan J Enghild
Sep 18, 1998·Biochimica Et Biophysica Acta·S RibierasM C Rio
Mar 29, 2003·Early Human Development·Jing LinMark W Babyatsky
Feb 24, 2006·Nature Reviews. Cancer·Stephen B Baylin, Joyce E Ohm
Oct 30, 1998·The Proceedings of the Nutrition Society·N J Seare, R J Playford
Apr 5, 2005·Toxicologic Pathology·David E MalarkeyRobert R Maronpot
Sep 16, 1998·The American Journal of Surgical Pathology·A M HanbyB Maguire
Feb 3, 1999·Annals of the New York Academy of Sciences·W R Otto, K Patel
May 14, 1999·Gut·W M WongN A Wright
Dec 14, 2006·The American Journal of Chinese Medicine·Xi-Ping LiRong Hu
Sep 14, 2007·Annual Review of Physiology·David J ThorntonMichael A McGuckin
Apr 8, 1999·American Journal of Respiratory and Critical Care Medicine·A WiedeW Hoffmann
Nov 6, 2001·American Journal of Respiratory Cell and Molecular Biology·M OertelW Hoffmann
Apr 15, 2008·BMC Gastroenterology·Hanna HaveriMarkku Heikinheimo
May 5, 2004·Proceedings of the National Academy of Sciences of the United States of America·Marguerite ClyneBrendan Drumm
Jul 1, 2005·Digestive Diseases and Sciences·Jeroen H B Van De BovenkampJan Dekker
Feb 9, 2013·Scandinavian Journal of Clinical and Laboratory Investigation·Mie Hessellund Samson
Jul 24, 2015·International Journal of Oncology·Werner Hoffmann
Nov 18, 2008·The Lancet Oncology·Ajay P SinghSurinder K Batra
Jun 12, 2012·International Journal of Otolaryngology·Jizhen LinJoseph E Kerschner
Dec 28, 1999·Gastroenterology·C TomasettoM C Rio

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