Room novelty, sex, scopolamine and their interactions as determinants of general activity and rearing, and light-dark preferences in rats

Behavioural Processes
Robert N HughesLaura C E Fisher

Abstract

Male and female rats were assessed for effects of scopolamine on general activity, rearing and light-dark preferences when tested in either a familiar or a novel room. Males but not females reared more often when tested in the familiar rather than novel room, and the response was increased by scopolamine for all rats combined. Whereas scopolamine increased general activity for females (but not males) in the familiar room, it decreased the response for males (but not females) in the novel room. Females crossed more often between the dark and light sides of a light-dark box and, when treated with saline but not drug, spent more time in the light side than males. Scopolamine reduced the amount of time spent in the light side for females only. While the results were discussed mainly in terms of sex differences in fearfulness, their principal value was in demonstrating the effectiveness of room novelty and sex in determining levels of the behaviors recorded, and drug responsiveness.

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Citations

Sep 15, 2012·Psychopharmacology·Amanda E D Van SwearingenCynthia M Kuhn
Jan 17, 2015·Toxins·Lijuan MaChunlin Long
Jan 3, 2013·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Christine M TenkKlaus-Peter Ossenkopp
Apr 20, 2010·Neuroscience and Biobehavioral Reviews·Inge Klinkenberg, Arjan Blokland
Aug 25, 2015·Frontiers in Behavioral Neuroscience·Naomi NagayaStephen Maren
Mar 25, 2014·Progress in Neuro-psychopharmacology & Biological Psychiatry·André de Macêdo MedeirosRegina Helena Silva
Jun 19, 2013·Physiology & Behavior·Mohammad-Reza ZarrindastAmeneh Rezayof
May 2, 2014·Frontiers in Aging Neuroscience·Shogo SomaSatoshi Shimegi
May 18, 2006·Reviews in the Neurosciences·Colin LeverJohn O'Keefe
Mar 18, 2021·The International Journal of Biochemistry & Cell Biology·Lidia I MadridDhanisha J Jhaveri

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