Roots and stems: stem cells in cancer

Nature Medicine
Kornelia Polyak, William C Hahn

Abstract

Cancer develops from normal tissues through the accumulation of genetic alterations that act in concert to confer malignant phenotypes. Although we have now identified some of the genes that when mutated initiate tumor formation and drive cancer progression, the identity of the cell population(s) susceptible to such transforming events remains undefined for the majority of human cancers. Recent work indicates that a small population of cells endowed with unique self-renewal properties and tumorigenic potential is present in some, and perhaps all, tumors. Although our understanding of the biology of these putative cancer stem cells remains rudimentary, the existence of such cells has implications for current conceptualizations of malignant transformation and therapeutic approaches to cancer.

References

Sep 1, 1988·The New England Journal of Medicine·B VogelsteinJ L Bos
Aug 1, 1985·Cell·J M Bishop
Jan 1, 1994·Cold Spring Harbor Symposia on Quantitative Biology·C B HarleyC W Greider
Jun 30, 1995·Annals of the New York Academy of Sciences·R A Weinberg
Oct 18, 1996·Cell·K W Kinzler, B Vogelstein
Jul 24, 1997·The New England Journal of Medicine·G J Bosl, R J Motzer
Mar 17, 2001·Nature Reviews. Molecular Cell Biology·J R Masters
Oct 5, 2001·Nature Reviews. Molecular Cell Biology·C J Sherr
Nov 2, 2001·Nature·A SpradlingT Kai
Apr 25, 2002·Nature Reviews. Genetics·Elaine Fuchs, Srikala Raghavan
Feb 6, 2003·Cytotherapy·M A Goodell
Mar 12, 2003·Proceedings of the National Academy of Sciences of the United States of America·Muhammad Al-HajjMichael F Clarke
May 14, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·William C Hahn
May 21, 2003·Genes & Development·Gabriela DontuMax S Wicha
Mar 14, 1956·Annals of the New York Academy of Sciences·S MAKINO
Sep 25, 2003·Proceedings of the National Academy of Sciences of the United States of America·Emmanuelle PasseguéIrving L Weissman
Oct 3, 2003·Cell Proliferation·Gabriela DontuMax S Wicha
Dec 12, 2003·Nature Reviews. Cancer·Matthew Smalley, Alan Ashworth
Dec 13, 2003·Science·Tudorita TumbarElaine Fuchs
Jan 9, 2004·Proceedings of the National Academy of Sciences of the United States of America·Toru KondoTetsuya Taga
Jan 23, 2004·Nature Reviews. Cancer·Ricardo PardalSean J Morrison
Feb 26, 2004·Cell Biochemistry and Biophysics·Henry E YoungAsa C Black
Mar 9, 2004·Cell Cycle·Julie M Bailis, Susan L Forsburg
Mar 9, 2004·Cell Cycle·Takao SetoguchiToru Kondo
Mar 11, 2004·The International Journal of Biochemistry & Cell Biology·Robert Y L Tsai
Mar 24, 2004·Cell·Elaine FuchsGeraldine Guasch
Apr 28, 2004·Current Opinion in Genetics & Development·Muhammad Al-HajjMichael F Clarke
Aug 3, 2004·Nature Medicine·Bert Vogelstein, Kenneth W Kinzler
Aug 19, 2004·Cell·Merel E Valk-LingbeekMaarten van Lohuizen
Sep 21, 2004·Oncogene·Muhammad Al-Hajj, Michael F Clarke
Sep 24, 2004·Proceedings of the National Academy of Sciences of the United States of America·C Hirschmann-JaxM K Brenner
Nov 19, 2004·Nature·Philip A BeachyDavid M Berman
Apr 2, 2005·Nature Reviews. Cancer·Michael DeanSusan Bates
Apr 15, 2005·Nature·Tannishtha Reya, Hans Clevers
Apr 23, 2005·Cancer Biology & Therapy·Richard C Bates, Arthur M Mercurio
Jun 2, 2005·Proceedings of the National Academy of Sciences of the United States of America·Kenkichi MasutomiWilliam C Hahn
Jul 23, 2005·Science·Ignacio FloresMaría A Blasco

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Citations

Sep 13, 2007·Stem Cell Reviews·Andrew C BoquestPhilippe Collas
Feb 18, 2009·Cancer Immunology, Immunotherapy : CII·Craig GedyeIan D Davis
Nov 21, 2008·International Archives of Occupational and Environmental Health·Dirk TaegerBeate Pesch
Apr 9, 2013·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Slavica StojnevTakanori Hattori
Oct 30, 2007·Breast Cancer Research and Treatment·Jiangbing ZhouYing Zhang
Dec 14, 2006·Cancer Metastasis Reviews·Jianhua WangRussell S Taichman
Jul 25, 2007·Cancer Metastasis Reviews·Bryan C Barnhart, M Celeste Simon
Sep 15, 2010·Cancer Metastasis Reviews·Xueqing SunJianhua Wang
Jun 15, 2007·Journal of Mammary Gland Biology and Neoplasia·Xin Lu, Yibin Kang
Apr 22, 2009·Journal of Mammary Gland Biology and Neoplasia·Traci R LyonsVirginia F Borges
May 2, 2009·Journal of Mammary Gland Biology and Neoplasia·Jenifer Monks, Peter M Henson
Sep 29, 2006·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·José A Martínez-ClimentFelipe Prosper
Jun 1, 2011·Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society·Kai BartkowiakKlaus Pantel
Mar 6, 2009·Proceedings of the National Academy of Sciences of the United States of America·Kimberly D SiegmundDarryl Shibata
Aug 12, 2009·Proceedings of the National Academy of Sciences of the United States of America·Keith Syson ChanIrving L Weissman
Sep 29, 2012·Proceedings of the National Academy of Sciences of the United States of America·Shannon M McAuliffeDaniela M Dinulescu
Apr 21, 2011·Antioxidants & Redox Signaling·Renata ZobalovaJiri Neuzil
Aug 22, 2007·Rejuvenation Research·Gesche TallenKarl Riabowol
Jan 31, 2013·Stem Cells and Development·Bizunesh M BorenaGerlinde R Van de Walle
Oct 28, 2009·Carcinogenesis·C MaenhautW C G van Staveren
Oct 11, 2007·Journal of the National Cancer Institute·S Lilly ZhengWilliam B Isaacs
Nov 13, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Erik J TokarMichael P Waalkes
Sep 16, 2010·Current Opinion in Oncology·Fabrice AndreChristine Desmedt
Oct 9, 2007·The Cancer Journal·Madhuri Kakarala, Max S Wicha
Oct 16, 2010·Pathology International·Minako HagikuraMasahide Takahashi
Sep 2, 2008·Cancer Research·Christine OdouxEric Lagasse
Jan 28, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·So Yeon ParkKornelia Polyak
Jan 28, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Tiziano Di TomasoCristina Maccalli
Nov 26, 2008·Journal of Ovarian Research·Nicholas B Berry, Sharmila A Bapat
Sep 18, 2013·Breast Cancer Research : BCR·Jagdeep K SinghRobert B Clarke
Dec 3, 2008·Disease Models & Mechanisms·Néstor J OviedoAlejandro Sánchez Alvarado
Oct 13, 2007·Annals of Surgical Oncology·Keisuke IetaMasaki Mori
Apr 28, 2011·Annals of Surgical Oncology·Masahisa OhkumaMasaki Mori
Oct 12, 2013·PloS One·Barbara HämmerleJaime Font de Mora
Jan 1, 2009·Immunotherapy·Trina J Stewart, Mark J Smyth
Nov 13, 2010·Folia Histochemica Et Cytobiologica·Bożena Dobrzycka, Sławomir J Terlikowski

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