ROP and ATRP fabricated redox sensitive micelles based on PCL-SS-PMAA diblock copolymers to co-deliver PTX and CDDP for lung cancer therapy.

Colloids and Surfaces. B, Biointerfaces
Yu-Lun LoLi-Fang Wang

Abstract

Combining dual drugs in one vehicle to cancer cells offers spatiotemporal localization of drug at the site of action, leading to synergistic therapeutic effects and reduced side effects. To improve pH/redox responsiveness to the tumor microenvironments for cancer therapy, a pH/redox-responsive micelle based on poly(ε-caprolactone)-SS-poly(methacrylic acid) (PCL-SS-PMAA) diblock copolymer was fabricated for dual drug delivery. The PCL-SS-PMAA was formulated into a core-shell micelle (PSPm) in an aqueous solution. The critical micelle concentration (CMC) values of PSPm were 7.94 × 10-3 mg mL-1 at pH 5.0 and 1.00 × 10-2 mg mL-1 at pH 7.4. The hydrodynamic diameters of PSPm were within 210-270 nm, depending on pH values. Changes in morphology and size of PSPm were clearly observed before and after exposure to a reducing agent. Paclitaxel (PTX) was encapsulated into the core and cisplatin (CDDP) was chelated on the shell of PSPm, with both PTX and CDDP being efficiently released from PSPm in the presence of a reducing agent in an acid condition. MTT and annexin V/propidium iodide dual staining results demonstrated that co-loading of CDDP and PTX into PSPm had a synergistic effect in killing lung cancer cells and exerted superior ant...Continue Reading

References

Dec 1, 1994·The Journal of Cell Biology·R G PartonK Simons
Aug 8, 2001·Journal of Controlled Release : Official Journal of the Controlled Release Society·N Nishiyama, K Kataoka
Aug 23, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·Natalya RapoportJared L Nelson
Apr 2, 2004·Nature Reviews. Cancer·Mary Ann Jordan, Leslie Wilson
Mar 2, 2006·Pharmacological Reviews·Ikramy A KhalilHideyoshi Harashima
Apr 25, 2006·Angewandte Chemie·Chengming LiAndrew L Lewis
Aug 29, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ji Sun ParkYong Woo Cho
Dec 23, 2006·Biochemical and Biophysical Research Communications·Oshrat Harush-FrenkelYoram Altschuler
May 24, 2008·The Biochemical Journal·Joshua Z Rappoport
Jun 18, 2009·Molecular Therapy : the Journal of the American Society of Gene Therapy·Hansjörg HufnagelFlorian Hollfelder
Dec 17, 2009·Molecular Therapy : the Journal of the American Society of Gene Therapy·Dries VercauterenKevin Braeckmans
Mar 24, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Nicolas Schüwer, Harm-Anton Klok
Jul 2, 2011·Colloids and Surfaces. B, Biointerfaces·Na SongJinyi Wang
Sep 2, 2011·Biomacromolecules·Behnoush Khorsand SourkohiJung Kwon Oh
Dec 2, 2011·Accounts of Chemical Research·Sejin SonWon Jong Kim
Jun 2, 2012·Drug Discovery Today·Priyambada ParhiSanjeeb Kumar Sahoo
Sep 29, 2012·Macromolecular Rapid Communications·Alexander Cunningham, Jung Kwon Oh
Jan 16, 2013·Chemical Communications : Chem Comm·Sandra Binauld, Martina H Stenzel
Nov 26, 2013·Advanced Drug Delivery Reviews·Nicolas BertrandOmid C Farokhzad
Aug 28, 2014·Colloids and Surfaces. B, Biointerfaces·Alexander CunninghamJung Kwon Oh
Aug 30, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yan ZouZhiyuan Zhong
May 26, 2017·Journal of Controlled Release : Official Journal of the Controlled Release Society·Philip GrossenJörg Huwyler
Mar 20, 2018·Materials Science & Engineering. C, Materials for Biological Applications·Kehu ZhangZhongli Lei

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Citations

Jun 3, 2021·Pharmaceutics·Yuseon ShinKyungtaek Oh

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