Ropinirole: for the treatment of restless legs syndrome

CNS Drugs
Susan M CheerGillian M Keating

Abstract

Ropinirole is a non-ergoline dopamine agonist that exhibits a high affinity for D(2) and D(3) receptors but little or no affinity for D(1)-like and non-dopaminergic receptors. Symptoms of restless legs syndrome (RLS) [measured using the International Restless Legs scale and Clinical Global Impression-Global Improvement Scale scores] significantly improved with ropinirole compared with placebo in large, randomised, double-blind trials. Ropinirole reduced periodic leg movements and improved sleep efficiency relative to baseline and placebo in several trials (two of which were randomised, double-blind and relatively large) in patients with RLS. Ropinirole was generally well tolerated in patients with RLS; adverse events were generally mild to moderate in nature and consistent with those expected of dopamine agonists. Few patients receiving ropinirole withdrew from therapy because of adverse events, the most predominant of which were nausea and headache.

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Citations

Sep 1, 2006·Journal of Neurology·Wolfgang H JostOlivier Rascol
Jan 4, 2006·CNS Drug Reviews·Wolfgang H Jost, Dieter Angersbach
May 20, 2008·CNS Drugs·Pankaj Satija, William G Ondo
Mar 3, 2018·Psychopharmacology·Laura B FergusonRoy Dayne Mayfield
Feb 4, 2010·Clinical Neuropharmacology·Peter Hedera
Jan 1, 2011·International Journal of Medicinal Chemistry·Shin Hisahara, Shun Shimohama

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