RORA and posttraumatic stress trajectories: main effects and interactions with childhood physical abuse history

Brain and Behavior
Sarah R LoweKarestan C Koenen

Abstract

Longitudinal studies of posttraumatic stress (PTS) have documented environmental factors as predictors of trajectories of higher, versus lower, symptoms, among them experiences of childhood physical abuse. Although it is now well-accepted that genes and environments jointly shape the risk of PTS, no published studies have investigated genes, or gene-by-environment interactions (GxEs), as predictors of PTS trajectories. The purpose of this study was to fill this gap. We examined associations between variants of the retinoid-related orphan receptor alpha (RORA) gene and trajectory membership among a sample of predominantly non-Hispanic Black urban adults (N = 473). The RORA gene was selected based on its association with posttraumatic stress disorder (PTSD) in the first PTSD genome wide association study. Additionally, we explored GxEs between RORA variants and childhood physical abuse history. We found that the minor allele of the RORA SNP rs893290 was a significant predictor of membership in a trajectory of consistently high PTS, relatively to a trajectory of consistently low PTS. Additionally, the GxE of rs893290 with childhood physical abuse was significant. Decomposition of the interaction showed that minor allele frequency ...Continue Reading

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Citations

Nov 26, 2015·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Janitza L Montalvo-OrtizJoan Kaufman
Jun 2, 2018·European Psychiatry : the Journal of the Association of European Psychiatrists·Diogo Lamela, Bárbara Figueiredo
Oct 11, 2017·Harvard Review of Psychiatry·Mark W MillerDanielle R Miller
May 18, 2021·Chinese Journal of Traumatology = Zhonghua Chuang Shang Za Zhi·Yao-Guang ZhouWei-Zhi Liu

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BETA
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Mplus
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