RORγt(+) IL-22-producing NKp46(+) cells protect from hepatic ischemia reperfusion injury in mice

Journal of Hepatology
Elke EggenhoferAlexander Kroemer

Abstract

NKp46(+) cells are major effector cells in the pathogenesis of hepatic ischemia reperfusion injury (IRI). Nevertheless, the precise role of unconventional subsets like the IL-22-producing NKp46(+) cells (NK22) remains unknown. The purpose of this study was to examine the role of NK22 cells in IRI in transplantation, particularly with respect to regulation by the transcription factor ROR-gamma-t (RORγt). To explore the role of NK22 cells in IRI in the absence of adaptive immunity, B6.RORγt-(gfp/wt)-reporter and B6.RORγt-(gfp/gfp)-knockout (KO) mice on a Rag KO background underwent 90min partial warm ischemia, followed by 24h of reperfusion. Rag KO mice that possess fully functional NKp46(+) cells, and Rag-common-γ-chain-double-KO (Rag-γc-DKO) mice that lack T, B and NKp46(+) cells, were used as controls. We found that Rag-γc-DKO mice lacking NK22 cells show more severe levels of hepatocellular damage (GPT, histological injury) when compared to both Rag-RORγt-reporter and Rag KO mice that possess NK22 cells. Importantly, Rag-RORγt-reporter and Rag KO mice undergoing IRI expressed high protein levels of both IL-22 and GFP (RORγt), suggesting a protective role for RORγt(+) NK22 cells in IRI. Therefore, we tested the hypothesis that...Continue Reading

References

May 1, 1993·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H JaeschkeC W Smith
Jul 15, 1997·The Journal of Clinical Investigation·R M ZwackaJ F Engelhardt
Nov 26, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A B LentschM J Edwards
May 4, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Svetlana RadaevaBin Gao
Apr 9, 2005·Arthritis and Rheumatism·Hidekazu IkeuchiYoshihisa Nojima
Sep 13, 2005·Nature Medicine·Joshua N BeilkeRonald G Gill
Feb 14, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M E McNerneyM-L Alegre
Jul 26, 2006·The Journal of Experimental Medicine·Guang YuXian Chang Li
Nov 15, 2006·Immunological Reviews·Yoshihiro HayakawaMark J Smyth
Aug 25, 2007·Nature Reviews. Immunology·Nicholas D HuntingtonJames P Di Santo
Jan 19, 2008·The Journal of Clinical Investigation·Hak-Ling MaDeborah A Young
Feb 12, 2008·Nature Medicine·Shean J AujlaJay K Kolls
Apr 22, 2008·Nature Immunology·Eric VivierSophie Ugolini
Dec 23, 2008·Immunity·Lauren A ZenewiczRichard A Flavell
Jan 22, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Yoichiro UchidaJerzy W Kupiec-Weglinski
Feb 4, 2010·Seminars in Immunopathology·Kerstin WolkRobert Sabat
Feb 11, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Guido BeldiSimon C Robson
Sep 16, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Sung Hwan KiBin Gao
Jan 10, 2012·Annual Review of Immunology·Hergen Spits, Tom Cupedo
Jan 21, 2012·Transplantation·Paul J ChestovichJerzy W Kupiec-Weglinski
Mar 7, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Laura Gomez-SantosNaiara Beraza
Apr 5, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Xiaoni KongBin Gao
Aug 24, 2012·Transplantation·William van der TouwJonathan S Bromberg
Nov 10, 2012·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Y ZhangJ W Kupiec-Weglinski
Feb 24, 2015·Annual Review of Immunology·Jarrod A DudakovMarcel R M van den Brink

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Citations

Feb 29, 2020·International Journal of Molecular Sciences·Ricky H BhogalHynek Mergental
Jun 5, 2020·Clinical and Molecular Hepatology·Le Thi Thanh ThuyNorifumi Kawada
Jul 1, 2017·Frontiers in Immunology·Meifang Liu, Cai Zhang
Nov 8, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Dörte KleinschmidtSamuel Huber
Sep 7, 2020·Hepatology International·Xiaogang XiangBin Gao
Mar 23, 2021·JCI Insight·Laura M Cobb, Michael R Verneris

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