ROS-associated immune response and metabolism: a mechanistic approach with implication of various diseases.

Archives of Toxicology
Sharmistha BanerjeeParames C Sil

Abstract

The immune system plays a pivotal role in maintaining the defense mechanism against external agents and also internal danger signals. Metabolic programming of immune cells is required for functioning of different subsets of immune cells under different physiological conditions. The field of immunometabolism has gained ground because of its immense importance in coordination and balance of immune responses. Metabolism is very much related with production of energy and certain by-products. Reactive oxygen species (ROS) are generated as one of the by-products of various metabolic pathways. The amount, localization of ROS and redox status determine transcription of genes, and also influences the metabolism of immune cells. This review discusses ROS, metabolism of immune cells at different cellular conditions and sheds some light on how ROS might regulate immunometabolism.

References

Sep 1, 1992·Neurology·T OgawaS Saso
Oct 1, 1987·Annals of Internal Medicine·C E CrossD Harman
Dec 1, 1995·The Journal of Experimental Medicine·P JeanninJ Y Bonnefoy
Feb 1, 1997·Bioscience Reports·P R Gardner
Apr 1, 1997·Seminars in Cancer Biology·M J May, S Ghosh
Jun 24, 1998·Proceedings of the National Academy of Sciences of the United States of America·E ClementiS Moncada
Aug 11, 1998·Neuron·M J Berridge
Jan 20, 1999·Proceedings of the National Academy of Sciences of the United States of America·C BéraudP A Baeuerle
May 4, 1999·The Journal of Experimental Medicine·D H MunnA L Mellor
Jun 11, 1999·Journal of Cancer Research and Clinical Oncology·A M JanssenH W Verspaget
Jul 27, 1999·The American Journal of Cardiology·B V Howard
Nov 24, 1999·Free Radical Biology & Medicine·A P Arrigo
Nov 27, 1999·FEMS Immunology and Medical Microbiology·S E Geerlings, A I Hoepelman
May 23, 2000·Journal of Neural Transmission·B WidnerD Fuchs
Oct 3, 2002·Nature Reviews. Immunology·Qiutang Li, Inder M Verma
Feb 20, 2003·Proceedings of the National Academy of Sciences of the United States of America·Kui Lei, Roger J Davis
Oct 16, 2003·Molecular and Cellular Biology·Ann-Hwee LeeLaurie H Glimcher
Feb 19, 2004·Proceedings of the National Academy of Sciences of the United States of America·Roy G CutlerMark P Mattson
Aug 24, 2004·The Journal of Biological Chemistry·Hirohito Yamaguchi, Hong-Gang Wang
Jan 14, 2005·Molecular and Cellular Biochemistry·Marian ValkoJoshua Telser
Apr 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·John F FoleyJoshua M Farber
May 3, 2005·The Journal of Clinical Investigation·Kathryn E Wellen, Gökhan S Hotamisligil
Nov 16, 2005·Proceedings of the National Academy of Sciences of the United States of America·Aaron K NeumannLaurence A Turka
Dec 6, 2005·The Journal of Biological Chemistry·Karen MoreauNicole Dalla Venezia
Oct 7, 2006·Neurochemistry International·Zsuzsanna HartaiJános Kálmán
Oct 13, 2006·Annual Review of Pharmacology and Toxicology·Sten OrreniusBoris Zhivotovsky
Feb 3, 2007·Arteriosclerosis, Thrombosis, and Vascular Biology·Steve BonelloAgnes Görlach
Apr 17, 2007·Nature Neuroscience·Makiko NagaiSerge Przedborski
Jul 27, 2007·Proceedings of the National Academy of Sciences of the United States of America·Amir AbdollahiPeter E Huber
Nov 6, 2007·Antioxidants & Redox Signaling·Jyoti D Malhotra, Randal J Kaufman

❮ Previous
Next ❯

Citations

Feb 9, 2021·Archives of Toxicology·Marta Justyna KoziełAgnieszka Wanda Piastowska-Ciesielska

❮ Previous
Next ❯

Methods Mentioned

BETA
acetylation
GTPase
IEC
IECs
ubiquitination
nuclear translocation
protein folding

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of Biological Chemistry
Róisín M Loftus, David K Finlay
Immunology and Cell Biology
Jonathan D Schertzer, Gregory R Steinberg
Biochemistry. Biokhimii︠a︡
A Y AndreyevA A Starkov
© 2022 Meta ULC. All rights reserved