ROS-generating/ARE-activating capacity of metals in roadway particulate matter deposited in urban environment

Environmental Research
Timor Shuster-MeiselesYinon Rudich

Abstract

In this study we investigated the possible causal role for soluble metal species extracted from roadway traffic emissions in promoting particulate matter (PM)-induced reactive oxygen species (ROS) production and antioxidant response element (ARE) promoter activation. To this end, these responses have been evaluated in alveolar macrophage and epithelial lung cells that have been exposed to 'Unfiltered', 'Filtered' and 'Filtered+Chelexed' water extracts of PM samples collected from the roadway urban environments of Thessaloniki, Milan and London. Except for Thessaloniki, our results demonstrate that filtration resulted in a minor decrease in ROS activity of the fine PM fraction, suggesting that ROS activity is attributed mainly to water-soluble PM species. In contrast to ROS, ARE activity was mediated predominantly by the water-soluble component of PM present in both the fine and coarse extracts. Further removal of metals by Chelex treatment from filtered water extracts showed that soluble metal species are the major factors mediating ROS and ARE activities of the soluble fraction, especially in the London PM extracts. Finally, utilizing step-wise multiple-regression analysis, we show that 87% and 78% of the total variance observ...Continue Reading

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Citations

Feb 9, 2017·Environmental Science & Technology·James B BurkholderPaul J Ziemann
Jan 14, 2020·Environmental Science and Pollution Research International·Efthalia KogianniConstantini Samara
Mar 9, 2019·Environmental Science and Pollution Research International·Dongqing FangShuo Zhao
Jan 25, 2021·Environmental Monitoring and Assessment·E KogianniTh Lialiaris
Jan 27, 2021·Food & Function·Zhaohui XueXiaohong Kou
Oct 12, 2020·Environmental Research·Barbara A MaherRose Anne Kenny
Aug 6, 2019·Environmental Science & Technology·Tomasz Gonet, Barbara A Maher
Nov 8, 2017·Environmental Science & Technology·Manabu ShiraiwaKei Sato
Jan 31, 2019·Environmental Science & Technology·Collin BrehmerEllison Carter

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