ROS homeostasis, a key determinant in liver ischemic-preconditioning

Redox Biology
Ignacio Prieto, María Monsalve

Abstract

Reactive Oxygen Species (ROS) are key mediators of ischemia-reperfusion injury but also required for the induction of the stress response that limits tissue injury and underlies the protection provided by ischemic-preconditioning protocols. Liver steatosis is an important risk factor for liver transplant failure. Liver steatosis is associated with mitochondrial dysfunction and excessive mitochondrial ROS production. Studies aiming at decreasing the sensibility of the steatotic liver to ischemia-reperfusion injury using pre-conditioning protocols, have shown that the steatotic liver has a reduced capacity to respond to these protocols. Recent studies indicate that these effects are related to a reduced capacity of the steatotic liver to respond to elevated ROS levels following reperfusion by inducing a compensatory response. This failure to respond to ROS is associated with reduced levels of antioxidants, mitochondrial damage, hepatocyte cell death, activation of the immune system and induction of pro-fibrotic mediators.

Citations

Sep 19, 2019·Acta Cirúrgica Brasileira·Caio César Chaves CostaEdson Yuzur Yasojima
Jan 1, 2020·PloS One·Valerie ZabalaJennifer A Sanders
Feb 29, 2020·International Journal of Molecular Sciences·Ricky H BhogalHynek Mergental
Dec 24, 2018·International Journal of Molecular Sciences·Yuanyuan MengWenqing Xu
Mar 20, 2019·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Anding Liu, Haoshu Fang
May 22, 2020·Frontiers in Cell and Developmental Biology·Francesco BellantiGaetano Serviddio
Aug 23, 2020·Pharmaceutics·Lígia Nunes de Morais RibeiroBelchiolina Beatriz Fonseca
Aug 11, 2019·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Dai-Qiang LiuDa-Wei Ye
May 1, 2021·International Journal of Molecular Sciences·Siarhei A DabravolskiAlexander N Orekhov
Jul 6, 2021·Veterinary Medicine International·Sri Puji Astuti WahyuningsihBrigita Klara Krisdina Mamuaya

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BETA
nuclear translocation
biopsies

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