ROS-responsive mesoporous silica nanoparticles for MR imaging-guided photodynamically maneuvered chemotherapy

Nanoscale
Vijayakameswara Rao NJae Hyung Park

Abstract

Mesoporous silica nanoparticles (MSNs) with stimuli-responsive gatekeepers have been extensively investigated for controlled drug delivery at the target sites. Herein, we developed reactive oxygen species (ROS)-responsive MSNs (R-MSNs), consisting of a gadolinium (Gd)-DOTA complex as the ROS-responsive gatekeeper and polyethylene glycol (PEG)-conjugated chlorin e6 as the ROS generator, for magnetic resonance (MR) imaging-guided photodynamic chemotherapy. Doxorubicin (DOX), chosen as an anticancer drug, was physically encapsulated into DOTA-conjugated MSNs, followed by chemical crosslinking via the addition of GdCl3. DOX-R-MSNs could effectively maintain their structural integrity in a physiological environment for 7 days and show an enhanced in vitro T1-MR imaging signal for the Gd-DOTA complex. Upon 660 nm laser irradiation, the release rate of DOX from DOX-R-MSNs remarkably increased along with the disintegration of the gatekeeper, whereas DOX release was significantly retarded without irradiation. When DOX-R-MSNs were intravenously injected into tumor-bearing mice, they were effectively accumulated in tumor tissue, which was demonstrated using MR imaging. In addition, tumor growth was significantly suppressed by DOX-R-MSNs, ...Continue Reading

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Citations

Mar 23, 2019·Expert Opinion on Drug Delivery·Rafael R CastilloMaría Vallet-Regí
Jan 4, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Chuanhui SongWei Han
Aug 31, 2018·Frontiers in Bioengineering and Biotechnology·N Vijayakameswara RaoJae Hyung Park
Jun 17, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Liang ChenYunbing Wang
Oct 3, 2020·Pharmaceutics·N Vijayakameswara RaoJae Hyung Park
Sep 9, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Haonan LiKui Luo
Mar 19, 2021·Chemical Society Reviews·Yufei XueNicolas Hans Voelcker
Dec 24, 2020·International Journal of Molecular Sciences·Miguel Gisbert-GarzaránMaría Vallet-Regí
Mar 30, 2021·Langmuir : the ACS Journal of Surfaces and Colloids·Kuikui ZhangChongxin Shan
Apr 4, 2020·Anti-cancer Agents in Medicinal Chemistry·Ahmed El-HusseinPatience Mthunzi-Kufa

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Methods Mentioned

BETA
X-ray
confocal microscopy
FACS
flow cytometry
Fluorescence
xenograft
Dynamic light scattering
fluorescence activated cell sorting
xenografts

Software Mentioned

Guava Easycyte
FlowJo
Analysis Workstation

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