ROS1 expression in invasive ductal carcinoma of the breast related to proliferation activity

Yonsei Medical Journal
Minseob EomKwang Hwa Park

Abstract

ROS1 is an oncogene, expressed primarily in glioblastomas of the brain that has been hypothesized to mediate the effects of early stage tumor progression. In addition, it was reported that ROS1 expression was observed in diverse cancer tissue or cell lines and ROS1 is associated with the development of several tumors. However, ROS1 expression has not been studied in breast cancer to date. Therefore, we investigated ROS1 expression at the protein and gene level to compare expression patterns and to verify the association with prognostic factors in invasive ductal carcinoma (IDC) of the breast. Tissue samples from 203 patients were used. Forty-six cases were available for fresh tissue. We performed immunohistochemical staining and real-time polymerase chain reaction (PCR). ROS1 expression was significantly lower in proportion to higher histologic grade, higher mitotic counts, lower estrogen receptor expression, and a higher Ki-67 proliferation index, although ROS1 expression was not significantly associated with the survival rate. The result of real-time PCR revealed similar trends, however not statistically significant. Higher ROS1 expression may be associated with favorable prognostic factors of IDC and its expression in IDC is...Continue Reading

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Citations

Oct 3, 2019·Scientific Reports·Lydon Wainaina NyamburaPeter Walden
Dec 4, 2016·Cancer Metastasis Reviews·Jennifer L Hsu, Mien-Chie Hung
Sep 11, 2020·Cancers·Federica IsidoriElena Bonora
Dec 23, 2015·The International Journal of Biological Markers·Jie-Fei HanJin-Ji Yang
Sep 15, 2017·Journal of Clinical Pathology·Prodipto Pal, Zanobia Khan

Related Concepts

ROS1 protein, human
Mammary Neoplasms, Human
Immunocytochemistry
Protein Tyrosine Kinase
Proto-Oncogene Proteins
Survival Analysis
Mammary Ductal Carcinoma
Cell Proliferation
Gleason Grading System
Brain

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