Rosai-Dorfman disease revealed in the upper airway: a case report and review of the literature

Auris, Nasus, Larynx
Yoh-Ichiro Maeda, Keiichi Ichimura

Abstract

Rosai-Dorfman disease (RDD) is a systemic disease and its etiology is not well understood. It is a very rare but established disease. We report a case of RDD diagnosed in the upper airway that became a life-threatening condition because of the stricture of the subglottic space. A 49-year-old female complained of nasal obstruction, hoarseness and lacrimation. After evaluation following by fiberscopic examination and CT scanning of the head and neck, sinusitis and laryngeal masses were detected. Endoscopic sinus surgery and endolaryngeal microsurgery were performed simultaneously. The masses in the nasal cavity and larynx showed the same histological findings. Proliferative large histiocytes with voluminous clear cytoplasm and rounded nuclei, and lymphophagocytosis known as emperipolesis are the characteristic features of RDD. In this case, extranodal manifestations in the subglottic space gradually emerged postoperatively. Tracheotomy was performed to ensure an airway and prevent suffocation. An extensive treatment is not required in most patients with RDD, however, some patients who have extranodal manifestations involving the airway may detoriorate into a life-threatening condition.

References

Apr 4, 1998·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·T S SheenJ Y Ko
May 23, 2003·American Journal of Otolaryngology·Yu-Chien ChangAlex Ying-Shyuan Lee

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Citations

Mar 24, 2006·Journal of Endocrinological Investigation·S ArenaG L La Rosa
Apr 15, 2015·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Martin ReznitskyBirgitte Wittenborg Charabi
Apr 7, 2011·La Revue de médecine interne·A Coste
Jan 30, 2010·American Journal of Rhinology & Allergy·Malek BelcadhiKamel Bouzouita
Jun 3, 2011·International Journal of Surgical Pathology·Oluyomi Edith AjiseRosemary Wieczorek
Jun 7, 2020·Head and Neck Pathology·Aileen Azari-YaamMehrzad Mehdizadeh
Mar 23, 2006·Current Opinion in Otolaryngology & Head and Neck Surgery·Patrick J Bradley

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