Aug 1, 1977

Rosamicin in urethral and vaginal secretions and tissues in dogs and rats

Antimicrobial Agents and Chemotherapy
U HoymeP O Madsen

Abstract

In animal studies we investigated the distribution of rosamicin in plasma and urethral and vaginal tissues in rats as well as in urethral and vaginal secretions in dogs. We found concentration ratios between urethral secretion and plasma of 1.9 and between vaginal secretion and plasma of 2.4. The rosamicin concentrations in urethral and vaginal tissue significantly exceeded the levels of all other tissues investigated. Because rosamicin could be valuable for the treatment of bacterial urethritis and the colonization of the vaginal introitus with fecal bacteria in women, it should be investigated clinically in this respect.

Mentioned in this Paper

Urethra
Vaginal Introitus Structure
Aminoglycosides
Rosaramicin
Prostate
Vaginal Secretions
Introitus
Feces
Urethritis
Urethral Sphincters

About this Paper

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