Roscovitine inhibits ongoing DNA synthesis in human cervical cancer

Cancer Letters
Liliana VitaliVictor Idoyaga Vargas

Abstract

The effect of roscovitine, a purine analogue and cyclin dependent kinase inhibitor, on DNA synthesis rate in tissue mini-units obtained from human cervical cancers was investigated. Roscovitine (100 microM) gave a DNA synthesis rate inhibition by 61% (P<0.0001; range 23-93%) within 30 min of incubation. This inhibitory effect was concentration-dependent. The results suggest that the inhibition of tumor DNA synthesis rate is due to a direct effect on the DNA synthesis machinery via presently unknown mechanisms. In addition, the potential application of CDKs inhibitors as preventive agents is discussed.

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Citations

Feb 24, 2007·Cancer Chemotherapy and Pharmacology·Hairong SongZuzana Hassan
Apr 28, 2005·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Marina VitaMoustapha Hassan
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Aug 1, 2019·International Journal of Oncology·Yu LiuXiaorong Qi
Nov 6, 2009·The Journal of Biological Chemistry·Viktor YarotskyyKeith S Elmslie

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