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Roscovitine is a proteostasis regulator that corrects the trafficking defect of F508del-CFTR by a CDK-independent mechanism

British Journal of Pharmacology

Jul 30, 2014

Caroline NorezFrédéric Becq

Abstract

The most common mutation in cystic fibrosis (CF), F508del, causes defects in trafficking, channel gating and endocytosis of the CF transmembrane conductance regulator (CFTR) protein. Because CF is an orphan disease, therapeutic strategies aimed at improving mutant CFTR functions are nee...read more

Mentioned in this Paper

SCN5A protein, human
Biochemical Pathway
Protein Kinase Inhibitors
Cyclin-Dependent Kinases
HEK293 Cells
Endocytosis
Calcium
Squamous Transitional Epithelial Cell Count
Roscovitine
Biologic Development
30
Paper Details
References
  • References73
  • Citations6
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Roscovitine is a proteostasis regulator that corrects the trafficking defect of F508del-CFTR by a CDK-independent mechanism

British Journal of Pharmacology

Jul 30, 2014

Caroline NorezFrédéric Becq

PMID: 25065395

DOI: 10.1111/bph.12859

Abstract

The most common mutation in cystic fibrosis (CF), F508del, causes defects in trafficking, channel gating and endocytosis of the CF transmembrane conductance regulator (CFTR) protein. Because CF is an orphan disease, therapeutic strategies aimed at improving mutant CFTR functions are nee...read more

Mentioned in this Paper

SCN5A protein, human
Biochemical Pathway
Protein Kinase Inhibitors
Cyclin-Dependent Kinases
HEK293 Cells
Endocytosis
Calcium
Squamous Transitional Epithelial Cell Count
Roscovitine
Biologic Development
30

Similar Papers Found In These Feeds

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Paper Details
References
  • References73
  • Citations6
12345...
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