Rosemary (Rosmarinus officinalis L.) leaf extract limits weight gain and liver steatosis in mice fed a high-fat diet

Planta medica
Taoufiq HarachChristian Darimont

Abstract

The objective of this study was to investigate the effects of rosemary (Rosmarinus officinalis L.) leaf extract (RE) on the prevention of weight gain and associated metabolic disorders in mice fed a high-fat diet. For this purpose, RE was administered for 50 days at 20 or 200 mg/kg body weight (BW) to mice fed a high-fat diet. Body weight was monitored during the study and body composition was measured before and at the end of the intervention. Glucose tolerance, assessed by an intraperitoneal glucose tolerance test (IPGTT), and hepatic and faecal lipid contents were determined at the end of the study. Treatment with 200 mg/kg BW of RE induced a significant reduction of weight and fat mass gain (-64% and -57%, respectively) associated with an increase of faecal lipid excretion. This effect appears to be related to the inhibition of pancreatic lipase activity induced by RE, as demonstrated IN VITRO. While glucose tolerance and fasting glycaemia were not affected by RE treatment, hepatic triglyceride levels were decreased by 39% in RE-treated mice. Administration of the lower dose of RE (20 mg/kg BW) was ineffective on all the parameters measured. In conclusion, our results demonstrate that consumption of 200 mg/kg BW of RE can l...Continue Reading

Citations

Apr 19, 2011·Journal of Agricultural and Food Chemistry·Yeyi GuJoshua D Lambert
Apr 12, 2013·Metabolic Syndrome and Related Disorders·Mesfin YimamQi Jia
Jan 24, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Rainer W Bussmann
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Nov 22, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Pedro MenaDaniele Del Rio
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