ROSET Model of TonB Action in Gram-Negative Bacterial Iron Acquisition

Journal of Bacteriology
Phillip E Klebba

Abstract

The rotational surveillance and energy transfer (ROSET) model of TonB action suggests a mechanism by which the electrochemical proton gradient across the Gram-negative bacterial inner membrane (IM) promotes the transport of iron through ligand-gated porins (LGP) in the outer membrane (OM). TonB associates with the IM by an N-terminal hydrophobic helix that forms a complex with ExbBD. It also contains a central extended length of rigid polypeptide that spans the periplasm and a dimeric C-terminal-ββαβ-domain (CTD) with LysM motifs that binds the peptidoglycan (PG) layer beneath the OM bilayer. The TonB CTD forms a dimer with affinity for both PG- and TonB-independent OM proteins (e.g., OmpA), localizing it near the periplasmic interface of the OM bilayer. Porins and other OM proteins associate with PG, and this general affinity allows the TonB CTD dimer to survey the periplasmic surface of the OM bilayer. Energized rotational motion of the TonB N terminus in the fluid IM bilayer promotes the lateral movement of the TonB-ExbBD complex in the IM and of the TonB CTD dimer across the inner surface of the OM. When it encounters an accessible TonB box of a (ligand-bound) LGP, the monomeric form of the CTD binds and recruits it into a ...Continue Reading

References

Jun 1, 1976·Journal of Bacteriology·A P Pugsley, P Reeves
Apr 1, 1976·Journal of Bacteriology·R WayneJ B Neilands
Oct 1, 1976·Journal of Bacteriology·P J BassfordC A Schnaitman
Jan 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·I MunroL Stryer
Dec 1, 1977·Journal of Bacteriology·P J Bassford, R J kadner
Mar 16, 1976·European Journal of Biochemistry·C J Schmitges, U Henning
Jul 26, 1976·Biochemical and Biophysical Research Communications·P A Manning, P Reeves
Sep 1, 1987·Journal of Bacteriology·W J RocqueE J McGroarty
Mar 1, 1985·Microbiological Reviews·H Nikaido, M Vaara
Nov 24, 1986·FEBS Letters·J S EvansC F Higgins
Jun 1, 1973·Journal of Bacteriology·S K Guterman, L Dann
Mar 12, 1970·Biochemical and Biophysical Research Communications·J R Pollack, J B Neilands
Nov 10, 1995·The Journal of Biological Chemistry·J B Neilands
Dec 5, 1995·Biochemical and Biophysical Research Communications·B R TerryJ Haseloff
Apr 8, 1998·Microbiology and Molecular Biology Reviews : MMBR·J V Höltje
Apr 17, 1999·Medical Microbiology and Immunology·B A DmitrievE T Rietschel
Jun 26, 1999·Molecular Microbiology·S M NewtonP E Klebba
Sep 15, 1999·Proceedings of the National Academy of Sciences of the United States of America·N Cadieux, R J Kadner
Jun 2, 2000·The Journal of Membrane Biology·M H Saier
May 1, 2001·The Journal of Biological Chemistry·C ChangA Wlodawer
Oct 24, 2001·Biochemistry·S Kojima, D F Blair
Mar 2, 2002·Science·Andrew D FergusonJohann Deisenhofer
Aug 10, 2002·Journal of Bacteriology·Daniel C ScottPhillip E Klebba
Mar 26, 2003·Nature Structural Biology·David P ChimentoMichael C Wiener
May 20, 2003·Journal of Bacteriology·Boris A DmitrievStefan Ehlers
Sep 18, 2003·Journal of Bacteriology·Annette SauterVolkmar Braun
Dec 11, 2003·Microbiology and Molecular Biology Reviews : MMBR·Hiroshi Nikaido

❮ Previous
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Citations

Nov 3, 2016·Biophysical Journal·Arthur SikoraDavid S Cafiso
Nov 9, 2016·Trends in Molecular Medicine·Briana R WilsonYoshiaki Tsuji
Apr 22, 2017·Nature Communications·Samuel J HickmanDavid J Brockwell
May 23, 2017·Natural Product Reports·P Klahn, M Brönstrup
Mar 1, 2017·Journal of Bacteriology·Brittany L NairnPhillip E Klebba
Dec 30, 2016·Journal of Bacteriology·Heloise BalhesterosPhillip E Klebba
Feb 6, 2019·Infection and Immunity·Federica RunciPaolo Visca
Jan 27, 2019·The Journal of Biological Chemistry·Somnath ChakravortyPhillip E Klebba
Apr 21, 2019·Medicinal Research Reviews·Thanh-Nhat PhamPascal Sonnet
Jan 16, 2020·International Journal of Molecular Sciences·Herve CeliaSusan K Buchanan
Dec 19, 2019·Brazilian Journal of Microbiology : [publication of the Brazilian Society for Microbiology]·Gabriel Soares Guerra, Andrea Balan
Sep 16, 2020·Physical Chemistry Chemical Physics : PCCP·Salla I VirtanenO H Samuli Ollila
Apr 18, 2018·ELife·Saori Maki-YonekuraKoji Yonekura
Jul 26, 2018·Archives of Virology·Emma S Arguijo-HernándezLuis Kameyama
Apr 4, 2021·International Journal of Molecular Sciences·Véronique GasserIsabelle J Schalk
Jan 18, 2018·Biochemistry·Jessica L SarverDavid S Cafiso

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