Rosetting is associated with increased Plasmodium falciparum in vivo multiplication rate in the Saimiri sciureus monkey

Microbes and Infection
Cécile Le ScanfOdile Mercereau-Puijalon

Abstract

Severe Plasmodium falciparum malaria in African children is associated with high peripheral parasite densities and high rate of rosette-forming parasites. To explore the relationship between rosette formation and parasite density in vivo, we compared the multiplication rate of a rosette-forming variant (varO) of the Palo Alto line with a sibling non-rosetting variant (varR) in splenectomized Saimiri monkeys. The multiplication rate of varO parasites was 1.5-fold higher than that of the varR variant. This indicates that rosetting is indeed associated with high parasite multiplication efficiency in vivo and, as such, may contribute to the high parasite densities observed in severe malaria.

References

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Citations

Mar 16, 2011·Proceedings of the National Academy of Sciences of the United States of America·Alexandre JuilleratGraham A Bentley
Nov 22, 2012·Mediterranean Journal of Hematology and Infectious Diseases·Beatrice AutinoDonatella Taramelli
Jan 17, 2016·Malaria Journal·Micheline GuillotteOdile Mercereau-Puijalon
Jun 26, 2012·International Journal for Parasitology·Amy K Bei, Manoj T Duraisingh
Jul 19, 2012·PLoS Pathogens·Inès Vigan-WomasOdile Mercereau-Puijalon
Jan 23, 2017·Trends in Parasitology·Xue Yan YamPeter R Preiser
Nov 2, 2017·Molecular BioSystems·Xue Yan Yam, Peter R Preiser

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