Rosiglitazone, a peroxisome proliferator-activated receptor-gamma agonist, prevents hyperoxia-induced neonatal rat lung injury in vivo

Pediatric Pulmonology
Virender K RehanJohn S Torday

Abstract

Molecular disruption of homeostatic alveolar epithelial-mesenchymal interactions results in transdifferentiation of alveolar interstitial lipofibroblasts to myofibroblasts. Although this process was suggested to be a central molecular event in the pathogenesis of bronchopulmonary dysplasia (BPD), so far it has been only demonstrated in vitro; whether it also occurs in vivo is unknown. Our objectives were to determine if exposure to hyperoxia results in pulmonary alveolar lipo-to-myofibroblast transdifferentiation in vivo, and whether treatment with a potent peroxisome proliferator-activated receptor gamma (PPARgamma) (the key lipogenic fibroblast nuclear transcription factor) agonist, rosiglitazone, prevents this process. Newborn Sprague Dawley rat pups were exposed to control (21% O2), hyperoxia alone (95% O2 for 24 hr), or hyperoxia with rosiglitazone (95% O2 for 24 hr + rosiglitazone, 3 mg/kg, administered intraperitoneally) conditions. Subsequently, pups were sacrificed, and lung tissue was analyzed by morphometry, and by reverse transcription-polymerase chain reaction, Western hybridization, and immunohistochemistry for the expression of key lipogenic and myogenic markers. We observed a significant decrease in the expressi...Continue Reading

References

Aug 1, 1990·Differentiation; Research in Biological Diversity·K O LeslieR B Low
Aug 1, 1995·American Journal of Respiratory and Critical Care Medicine·J J CoalsonR A deLemos
Aug 15, 1995·Proceedings of the National Academy of Sciences of the United States of America·J C ClarkJ A Whitsett
Jan 20, 1995·Biochimica Et Biophysica Acta·J TordayR Slavin
Mar 1, 1995·American Journal of Respiratory Cell and Molecular Biology·C A RedlichJ A Elias
Jul 19, 1994·Proceedings of the National Academy of Sciences of the United States of America·S A KliewerR M Evans
Oct 1, 1995·Current Opinion in Genetics & Development·P TontonozB M Spiegelman
Jul 1, 1997·Pediatric Pulmonology·P TotiT A Seemayer
Oct 23, 1997·Microscopy Research and Technique·M A O'ReillyG S Pryhuber
May 19, 1998·Pediatric Research·M V SpezialeL J Deftos
Nov 18, 1998·Mayo Clinic Proceedings·J H RyuT E Hartman
Jan 28, 1999·American Journal of Respiratory Cell and Molecular Biology·M C BruceR J Cross
May 26, 1999·Current Topics in Pathology. Ergebnisse Der Pathologie·S H PhanM Gharaee-Kermani
Dec 10, 1999·Pediatric Research·A J Jobe
Dec 29, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A GalliA Casini
Jun 3, 2000·Annual Review of Pharmacology and Toxicology·J C CortonA Stauber
Mar 14, 2001·American Journal of Respiratory Cell and Molecular Biology·J M ShannonR J Mason
Apr 24, 2001·Current Opinion in Pediatrics·A H Jobe, M Ikegami
May 29, 2001·Current Pharmaceutical Design·S R Hoare, T B Usdin
Jun 1, 2001·Pediatric Research·J S TordayV Rehan
Dec 6, 2001·American Journal of Respiratory and Critical Care Medicine·S H Abman
Feb 13, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·J S TordayL P Rubin
Mar 7, 2002·American Journal of Physiology. Cell Physiology·F Machinal-QuélinY Giudicelli
Jun 13, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·J S Torday, V K Rehan
Jul 13, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·C J SchultzJ S Torday
Aug 10, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·F DemayoJ S Torday
Nov 1, 2002·Molecular Genetics and Metabolism·László G BorosVirender K Rehan
Apr 2, 2003·Seminars in Neonatology : SN·Jacqueline J Coalson
Jun 10, 2003·Cell Biochemistry and Biophysics·V Rehan, J Torday
Jun 14, 2003·American Journal of Respiratory Cell and Molecular Biology·Tracey L BonfieldMary Jane Thomassen
Sep 27, 2003·American Journal of Respiratory Cell and Molecular Biology·Daniel A CulverMary Jane Thomassen
Oct 18, 2003·American Journal of Respiratory and Critical Care Medicine·Kazuhiro AsadaHirotoshi Nakamura
May 27, 2004·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Lewis P RubinHenry M Kronenberg
Jun 14, 2005·American Journal of Physiology. Lung Cellular and Molecular Physiology·Virender K RehanJohn S Torday

❮ Previous
Next ❯

Citations

Nov 28, 2006·Indian Journal of Pediatrics·Virender K Rehan
Oct 1, 2007·Integrative and Comparative Biology·John S TordaySteven F Perry
Jun 18, 2009·Critical Care Medicine·Shyoko Honiden, Michelle N Gong
May 3, 2011·American Journal of Physiology. Lung Cellular and Molecular Physiology·Teodora NicolaYiu-Fai Chen
Aug 24, 2010·American Journal of Physiology. Lung Cellular and Molecular Physiology·Virender K RehanJohn S Torday
Mar 24, 2009·American Journal of Physiology. Lung Cellular and Molecular Physiology·Chiranjib DasguptaVirender K Rehan
Jul 11, 2012·PPAR Research·Ajit A KulkarniPatricia J Sime
Mar 22, 2008·American Journal of Respiratory and Critical Care Medicine·Alexander HoetzelAugustine M K Choi
Mar 13, 2010·American Journal of Respiratory and Critical Care Medicine·Hye-Youn ChoSteven R Kleeberger
Sep 10, 2009·American Journal of Respiratory Cell and Molecular Biology·Arul VadivelBernard Thébaud
Dec 24, 2010·American Journal of Respiratory Cell and Molecular Biology·Elisa GhelfiSule Cataltepe
Jan 24, 2012·American Journal of Respiratory Cell and Molecular Biology·Brian M VariscoJames S Hagood
Jun 2, 2012·American Journal of Respiratory Cell and Molecular Biology·Leiling ChenAnne-Karina T Perl
Oct 31, 2012·BMC Medicine·Virender K RehanJohn S Torday
Aug 16, 2008·Pediatric Research·Lynette K RogersStephen E Welty
Mar 29, 2014·Pediatric Allergy, Immunology, and Pulmonology·Christopher D BakerPeter M Mourani
Jul 14, 2012·PPAR Research·Virender K Rehan, John S Torday
Jan 7, 2014·Antioxidants & Redox Signaling·Virender K Rehan, John S Torday
Dec 20, 2013·Antioxidants & Redox Signaling·Jennifer J P Collins, Bernard Thébaud
Nov 9, 2006·Experimental Lung Research·Virender K RehanJohn S Torday
Nov 30, 2011·Birth Defects Research. Part A, Clinical and Molecular Teratology·Shawn K Ahlfeld, Simon J Conway
May 23, 2017·American Journal of Respiratory Cell and Molecular Biology·Stephen E McGowan, Diann M McCoy
Mar 23, 2011·Birth Defects Research. Part A, Clinical and Molecular Teratology·Lisa A Joss-MooreRobert H Lane
Oct 4, 2008·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Stephen E McGowanAmey J Holmes
Nov 7, 2006·American Journal of Physiology. Lung Cellular and Molecular Physiology·J S Torday, V K Rehan
Jan 1, 2014·American Journal of Physiology. Lung Cellular and Molecular Physiology·Jason GienSteven H Abman
Aug 8, 2018·Respiratory Research·José Alberto Rodríguez-CastilloKatrin Ahlbrecht
Aug 9, 2011·American Journal of Physiology. Lung Cellular and Molecular Physiology·Reiko SakuraiVirender K Rehan
Nov 3, 2016·American Journal of Physiology. Lung Cellular and Molecular Physiology·Shannon H LacyRichard P Phipps
Sep 1, 2015·American Journal of Physiology. Lung Cellular and Molecular Physiology·Aglaia NtokouKatrin Ahlbrecht
Oct 19, 2017·Genesis : the Journal of Genetics and Development·Aglaia NtokouKatrin Ahlbrecht
Jul 7, 2017·Pulmonary Circulation·Kara N GossSteven H Abman
Jan 8, 2021·Journal of Developmental Origins of Health and Disease·Jiaqi RenJanna L Morrison

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.