Rosiglitazone ameliorates diabetic nephropathy by reducing the expression of Chemerin and ChemR23 in the kidney of streptozotocin-induced diabetic rats.

Inflammation
Wenchao HuDemin Liu

Abstract

Chemerin is shown to be associated with inflammation which is involved in the pathogenesis of diabetic nephropathy. This study aims to determine whether rosiglitazone and pioglitazone ameliorate renal function through an effect on the expression of chemerin and ChemR23 in streptozotocin-induced diabetic rats. The rats were randomized to control, diabetic, rosiglitazone-, and pioglitazone-treated groups. The expression level of chemerin and ChemR23 in the renal tissues was significantly elevated in the diabetic group compared with the control group. Rosiglitazone inhibited the overexpression of chemerin and ChemR23, while pioglitazone inhibited the overexpression of ChemR23 in the kidney of diabetic rats. In addition, chemerin expression level was positively correlated with transforming growth factor-β1, connective tissue growth factor, tumor necrosis factor-α, and intracellular cell adhesion molecule-1 expression in diabetic rats. Rosiglitazone ameliorates diabetic nephropathy by reducing the expression of chemerin and ChemR23 in diabetic rats.

References

Mar 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·T YamamotoW A Border
Apr 6, 2000·American Journal of Physiology. Renal Physiology·D C HanF N Ziyadeh
Mar 10, 2001·Recent Progress in Hormone Research·H E Lebovitz, M A Banerji
Apr 3, 2001·Current Pharmaceutical Design·A S Wagman, J M Nuss
Jul 23, 2003·Journal of the American Society of Nephrology : JASN·Susan B ConnollyHugh R Brady
Apr 29, 2005·Journal of the American Society of Nephrology : JASN·Fiona Y ChowGregory H Tesch
Jul 20, 2007·The Journal of Biological Chemistry·Kerry B GoralskiChristopher J Sinal
Sep 5, 2007·Biochemical and Biophysical Research Communications·Sang-gun RohShin-ichi Sasaki
May 10, 2008·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·L ChenB Wang
Sep 4, 2008·Journal of Periodontology·George L King
Feb 17, 2009·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·David StejskalMarek Svestak
May 28, 2009·The Journal of Clinical Endocrinology and Metabolism·Kiymet BozaogluJeremy B M Jowett
Jun 30, 2009·Clinical Endocrinology·Johanna WeigertChrista Buechler
Oct 20, 2009·Diabetes Care·Dörte PfauMathias Fasshauer
Jan 30, 2010·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Pantelis A SarafidisAnastasios N Lasaridis
Jun 15, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Tae YamamotoJonas Axelsson
Aug 20, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rosie Hart, David R Greaves
Sep 14, 2010·Diabetes Research and Clinical Practice·G Derosa, P Maffioli
Oct 26, 2010·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·T BaranowskiM Fasshauer
Dec 15, 2010·Diabetes Research and Clinical Practice·Wenchao Hu, Ping Feng

❮ Previous
Next ❯

Citations

Nov 8, 2015·Vascular Pharmacology·Mario Bonomini, Assunta Pandolfi
Dec 12, 2012·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·J L RourkeC J Sinal
May 21, 2014·Journal of Diabetes Investigation·Alireza EsteghamatiManouchehr Nakhjavani
Apr 6, 2013·Arteriosclerosis, Thrombosis, and Vascular Biology·Stephanie W WattsGregory D Fink
May 27, 2020·American Journal of Hypertension·David J FerlandStephanie W Watts
Apr 26, 2016·Molecular Medicine Reports·Yao-Wu LiuXiao-Xing Yin
Oct 16, 2013·Molecular Medicine Reports·Ying HuangXueqing Yu
Feb 21, 2019·Journal of Cellular and Molecular Medicine·Jin ShangZhanzheng Zhao
Jun 2, 2018·Current Osteoporosis Reports·Shanmugam MuruganandanChristopher J Sinal
May 1, 2021·International Journal of Molecular Sciences·Rosaria Vincenza GiglioManfredi Rizzo

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Related Papers

Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
Xuewei FengJian Kang
Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
Ke HuangBo Zhang
© 2022 Meta ULC. All rights reserved